文献詳細
増刊号 6年前の常識は現在の非常識!—AI時代へ向かう今日の眼科医へ
Ⅷ.網膜
文献概要
ここが変わった!
以前の常識
・薬剤①:ラニビズマブとアフリベルセプトのみ
・薬剤②:先行バイオ医薬品のみ
・投与レジメン:必要に応じて(PRN),2か月に1回(bimonthly),treat and extend(TAE)
・適応:新生血管型加齢黄斑変性,近視性脈絡膜新生血管,糖尿病黄斑浮腫,網膜静脈閉塞症に伴う黄斑浮腫
現在の常識
・薬剤①:ブロルシズマブ,ファリシマブが登場
・薬剤②:バイオシミラーが登場
・投与レジメン:レスキュー付き3〜4か月ごと投与
・適応:血管新生緑内障,未熟児網膜症
以前の常識
・薬剤①:ラニビズマブとアフリベルセプトのみ
・薬剤②:先行バイオ医薬品のみ
・投与レジメン:必要に応じて(PRN),2か月に1回(bimonthly),treat and extend(TAE)
・適応:新生血管型加齢黄斑変性,近視性脈絡膜新生血管,糖尿病黄斑浮腫,網膜静脈閉塞症に伴う黄斑浮腫
現在の常識
・薬剤①:ブロルシズマブ,ファリシマブが登場
・薬剤②:バイオシミラーが登場
・投与レジメン:レスキュー付き3〜4か月ごと投与
・適応:血管新生緑内障,未熟児網膜症
参考文献
1)Dugel PU, Koh A, Ogura Y, et al:HAWK and HARRIER:phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration. Ophthalmology 127:72-84, 2020
2)Dugel PU, Singh RP, Koh A, et al:HAWK and HARRIER:ninety-six-week outcomes from the phase 3 trials of brolucizumab for neovascular age-related macular degeneration. Ophthalmology 128:89-99, 2021
3)Brown DM, Emanuelli A, Bandello F, et al:KESTREL and KITE:52-week results from two phase Ⅲ pivotal trials of brolucizumab for diabetic macular edema. Am J Ophthalmol 238:157-172, 2022
4)Monés J, Srivastava SK, Jaffe GJ, et al:Risk of inflammation, retinal vasculitis, and retinal occlusion-related events with brolucizumab:post hoc review of HAWK and HARRIER. Ophthalmology 128:1050-1059, 2021
5)Maruko I, Okada AA, Iida T, et al:Brolucizumab-related intraocular inflammation in Japanese patients with age-related macular degeneration:a short-term multicenter study. Graefes Arch Clin Exp Ophthalmol 259:2857-2859, 2021
6)Hikichi T:Sub-Tenon's capsule triamcinolone acetonide injection to prevent brolucizumab-associated intraocular inflammation. Graefes Arch Clin Exp Ophthalmol 260:2529-2535, 2022
7)Joussen AM, Ricci F, Paris LP, et al:Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases:a review of preclinical data. Eye(Lond) 35:1305-1316, 2021
8)Heier JS, Khanani AM, Ruiz CQ, et al:Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration(TENAYA and LUCERNE):two randomized, double-masked, phase 3, non-inferiority trials. Lancet 399:729-740, 2022
9)Khanani AM, Kotecha A, Chang A, et al:TENAYA and LUCERNE:two-year results from the phase 3 neovascular age-related macular degeneration trials of faricimab with treat-and-extend dosing in year 2. Ophthalmology 131:914-926, 2024
10)Wykoff CC, Abreu F, Adamis AP, et al:Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema(YOSEMITE and RHINE):two randomized, double-masked, phase 3 trials. Lancet 399:741-755, 2022
11)Wong TY, Haskova Z, Asik K, et al:Faricimab treat-and-extend for diabetic macular edema:two-year results from the randomized phase 3 YOSEMITE and RHINE trials. Ophthalmology 131:708-723, 2024
12)Tadayoni R, Paris LP, Danzig CJ, et al:Efficacy and safety of faricimab for macular edema due to retinal vein occlusion:24-week results from the BALATON and COMINO trials. Ophthalmology 131:950-960, 2024
13)Lanzetta P, Korobelnik JF, Heier JS, et al:Intravitreal aflibercept 8mg in neovascular age-related macular degeneration(PULSAR):48-week results from a randomized, double-masked, non-inferiority, phase 3 trial. Lancet 403:1141-1152, 2024
14)Brown DM, Boyer DS, Do DV, et al:Intravitreal aflibercept 8mg in diabetic macular oedema(PHOTON):48-week results from a randomized, double-masked, non-inferiority, phase 2/3 trial. Lancet 403:1153-1163, 2024
15)Brwon DM, Wykoff CC, Wong TP, et al:RAVE study group:Ranibizumab in preproliferative(ischemic)central retinal vein occlusion:the rubeosis anti-VEGF(RAVE)trial. Retina 34:1728-1735, 2014
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