臨床眼科78巻13号

2024年12月発行

特集 生活習慣と眼の病気のビミョーな関係。

脂肪酸摂取と網膜疾患

著者： 佐々木真理子¹²

所属機関： ¹慶應義塾大学医学部眼科学教室 ²国立病院機構東京医療センター眼科

ページ範囲：P.1495 - P.1503

文献概要

●脂肪酸は網膜の重要な構成要素であり，必須脂肪酸は体内で合成されないため，食事からの摂取が必要である。

●n-3系多価不飽和脂肪酸や，それを豊富に含む青魚や地中海食では網膜疾患の予防効果が報告されている。

●欧米人と遺伝的背景や生活習慣が異なる日本人では，脂肪酸摂取による網膜疾患への効果も異なる可能性がある。

参考文献

1）Schnebelen C, Viau S, Grégoire S, et al：Nutrition for the eye：different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. Ophthalmic Res 41：216-224, 2009

2）Chong EW, Kreis AJ, Wong TY, et al：Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration：a systematic review and meta-analysis. Arch Ophthalmol 126：826-833, 2008

3）Díaz-López A, Babio N, Martínez-González MA, et al：Mediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications：a post hoc analysis of a randomized trial. Diabetes Care 38：2134-2141, 2015

4）Sala-Vila A, Díaz-López A, Valls-Pedret C, et al：Dietary marine ω-3 fatty acids and incident sight-threatening retinopathy in middle-aged and older individuals with type 2 diabetes：prospective investigation from the PREDIMED trial. JAMA Ophthalmol 134：1142-1149, 2016

5）Sasaki M, Kawasaki R, Rogers S, et al：The associations of dietary intake of polyunsaturated fatty acids with diabetic retinopathy in well-controlled diabetes. Invest Ophthalmol Vis Sci 56：7473-7479, 2015

6）Haritoglou C, Gerss J, Hammes HP, et al：Alpha-lipoic acid for the prevention of diabetic macular edema. Ophthalmologica 226：127-137, 2011

7）Sammons EL, Buck G, Bowman LJ, et al：ASCEND-Eye：Effects of omega-3 fatty acids on diabetic retinopathy. Ophthalmology 131：526-533, 2024

8）SanGiovanni JP, Chew EY：The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res 24：87-138, 2005

9）Fliesler SJ, Anderson RE：Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 22：79-131, 1983

10）Connor KM, SanGiovanni JP, Lofqvist C, et al：Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 13：868-873, 2007

11）Alcubierre N, Navarrete-Muñoz EM, Rubinat E, et al：Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients：a case-control study. Nutr Metab（Lond） 13：40, 2016

12）Lee Y, Lee L, Zhang L, et al：Association between fatty acid intake and age-related macular degeneration：a meta-analysis. Front Nutr 11：1403987, 2024

13）Seddon JM, Rosner B, Sperduto RD, et al：Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol 119：1191-1199, 2001

14）Age-Related Eye Disease Study 2 Research Group：Lutein＋zeaxanthin and omega-3 fatty acids for age-related macular degeneration：the Age-Related Eye Disease Study 2（AREDS2）randomized clinical trial. JAMA 309：2005-2015, 2013

15）Souied EH, Delcourt C, Querques G, et al：Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration：the Nutritional AMD Treatment 2 study. Ophthalmology 120：1619-1631, 2013

16）Agrón E, Mares J, Clemons TE, et al：Dietary nutrient intake and progression to late age-related macular degeneration in the Age-Related Eye Disease Studies 1 and 2. Ophthalmology 128：425-442, 2021

17）Keenan TD, Agrón E, Mares J, et al：Adherence to the mediterranean diet and progression to late age-related macular degeneration in the Age-Related Eye Disease Studies 1 and 2. Ophthalmology 127：1515-1528, 2020

18）Sasaki M, Harada S, Tsubota K, et al：Dietary saturated fatty acid intake and early age-related macular degeneration in a Japanese population. Invest Ophthalmol Vis Sci 61：23, 2020

19）Roh M, Shin HJ, Laíns I, et al：Higher intake of polyunsaturated fatty acid and monounsaturated fatty acid is inversely associated with AMD. Invest Ophthalmol Vis Sci 61：20, 2020

20）Sasaki M, Yuki K, Hanyuda A, et al：Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Sci Rep 13：12903, 2023

21）Yasukawa T, Sasaki M, Motomura K, et al：Association between fatty acid intakes and age-related macular degeneration in a Japanese population：JPHC-NEXT Eye Study. Transl Vis Sci Technol 12：3, 2023

22）Aoki A, Inoue M, Nguyen E, et al：Dietary n-3 fatty acid, alpha-tocopherol, zinc, vitamin D, vitamin C, and beta-carotene are associated with age-related macular degeneration in Japan. Sci Rep 6：20723, 2016

23）van Leeuwen EM, Emri E, Merle BMJ, et al：A new perspective on lipid research in age-related macular degeneration. Prog Retin Eye Res 67：56-86, 2018

24）Wu J, Cho E, Giovannucci EL, et al：Dietary intakes of eicosapentaenoic acid and docosahexaenoic acid and risk of age-related macular degeneration. Ophthalmology 124：634-643, 2017

25）Jiang B, Wei X, Cai D, et al：Association between dietary consumption of fatty acids and age-related macular degeneration in the National Health and Nutrition Examination Survey. Sci Rep 14：11016, 2024

26）Sasaki M, Miyagawa N, Harada S, et al：Dietary patterns and their associations with intermediate age-related macular degeneration in a Japanese population. J Clin Med 11：1617, 2022