生体の科学11巻6号

1960年12月発行

Symposium On Active Transport

Biochemical and Electrophysiological Aspects of Gastric Acid Secretion

著者：

所属機関： ¹

ページ範囲：P.297 - P.304

　1．The H^＋ ion secretion, O₂ intake and lactic acid production of the toad mucosa under the influence of metabolic inhibits were measured, and some relations among the H^＋ion secretion, O₂ intake and lactic acid production have been discussed．
　2．The H^＋ ion secretion and O₂ intake of toad mucosa were measured under various concentrations of ethyl-urethane．The H^＋ ion secretion was strongly inhibited by 3％ ethyl-urethane, while the O₂ intake was only slightly inhibited．
　3．Generally, pentabarbital-Na inhibited the H^＋ ion secretion and O₂ intake, but at concentrations less than 1mM the H^＋ ion secretion and O₂ intake were promoted．These promoting effects were disturbed by Ringer solution containing K ion of 60mM．
　4．The P. D. and d. c. resistance of mucosa during the lag period of H^＋ ion secretion were found．The P. D. and the resistance of mucosa reached a steady value when the H^＋ ion secretion began to take place．
　5．The relations between the P. D. and the NaNO₃ concentration were observed．They indicated a straight line relationship．
　6．The H^＋ ions produced under an aerobic condition were drawn out from the mucosa under aerobic conditions of more than 15 minutes could be drawn out．The rise or fall in the P. D. had an influence on drawing of H^＋ ion, but when the mucosa was under the anaerobic condition from the beginning, the P. D. showed no influence on the H^＋ ion secretion．Based on foregoing facts, a driving mechanism is suggested for the acid secretion：the H^＋ ion is produced by aerobic metabolism and transportation of H^＋ or XH^＋ is performed by an electrical energy．