文献詳細
特集 細胞毒マニュアル—実験に用いられる細胞毒の知識
神経系に作用するもの 軸索・興奮性膜作用薬
文献概要
■Introduction
Neurotoxins have been isolated from a variety of sea anemone species and have become useful tools in physiological, pharmacological and biochemical studies.
It has been known for a decade that a polypeptide from the Bermuda anemone Condylactis gigantea, greatly prolongs the closing(inactivation)of Na+ channels in crustacean(but not squid)axons.These, and other, effects can now be associated with specific polypeptides from several coelenterates.Many neurotoxins are also cardiotoxins.
Neurotoxins have been isolated from a variety of sea anemone species and have become useful tools in physiological, pharmacological and biochemical studies.
It has been known for a decade that a polypeptide from the Bermuda anemone Condylactis gigantea, greatly prolongs the closing(inactivation)of Na+ channels in crustacean(but not squid)axons.These, and other, effects can now be associated with specific polypeptides from several coelenterates.Many neurotoxins are also cardiotoxins.
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