臨床泌尿器科65巻10号

2011年09月発行

特集 頻尿・切迫性尿失禁

膀胱知覚伝達に関する最新知見

著者： 相澤直樹¹ 井川靖彦¹

所属機関： ¹東京大学大学院医学系研究科コンチネンス医学講座

ページ範囲：P.715 - P.720

文献概要

要旨　過活動膀胱や間質性膀胱炎において，近年，膀胱知覚伝達路が大いに注目されている。膀胱における知覚伝達路に大きな役割を果たすのは，尿路上皮，間質および求心性神経である。求心性神経としては，2種類（Aδ線維とC線維）の神経線維が膀胱における正常な尿の充満知覚（尿意）および非生理的な異常知覚（尿意切迫感，膀胱痛など）を伝える役割を果たしていると考えられている。これらの膀胱知覚伝達のメカニズムに関する最新知見を概説した。

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