臨床泌尿器科66巻12号

2012年11月発行

セミナー テストステロンを再考する・5

女性におけるテストステロン

著者： 安井敏之¹

所属機関： ¹徳島大学大学院ヘルスバイオサイエンス研究部保健科学部門看護学講座生殖補助医療学分野

ページ範囲：P.943 - P.951

文献概要

要約　テストステロンが女性の体にどのような影響を及ぼしているのかについては明らかではない。テストステロンレベルが高いことは，脂質代謝，糖代謝，血管機能の観点からは好ましくないと考えられるが，セクシャリティーを始めとするさまざまな症状にテストステロンは必要である。女性においては，テストステロンレベルが高すぎても，低すぎてもよくないことから，その効果を最大限に引きだす適切なテストステロンレベルの解明が望まれる。

参考文献

1）Yasui T, Matsui S, Tani A, et al：Androgen in postmenopausal women. J Med Invest 59：12-27, 2012

2）Braunstein GD：Androgen insufficiency in women：summary of critical issues. Fertil Steril 77：S94-99, 2002

3）Yasui T, Uemura H, Irahara M, et al：Differences in sensitivity to cold in Japanese men and postmenopausal women aged ＞－50 years. Gender Medicine 4：359-366, 2007

4）Spencer JB, Klein M, Kumar A, et al：The age-associated decline of androgens in reproductive age and menopausal black and white women. J Clin Endocrinol Metab 92：4730-4733, 2007

5）Khosla S, Melton LJ Ⅲ, Atkinson EJ, et al：Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women：a key role for bioavailable estrogen. J Clin Endocrinol Metab 83：2266-2274, 1998

6）Soules MR, Sherman S, Parrott E, et al：Executive summary：stages of reproductive aging workshop（STRAW）. Fertil Steril 76：874-878, 2001

7）Couzinet B, Meduri G, Lecce MG, et al：The postmenopausal ovary is not a major androgen-producing gland. J Clin Endocrinol Metab 86：5060-5066, 2001

8）Davison SL, Bell R, Donath S, et al：Androgen levels in adult females：changes with age, menopause and oophorectomy. J Clin Endocrinol Metab 90：3847-3853, 2005

9）Bui HN, Struys EA, Martens F, et al：Serum testosterone levels measured by isotope dilution-liquid chromatography-tandem mass spectrometry in postmenopausal women versus those in women who underwent bilateral oophorectomy. Ann Clin Biochem 47：248-252, 2010

10）Ryan J, Stanczyk FZ, Dennerstein L, et al：Hormone levels and cognitive function in postmenopausal midlife women. Neurobiol Aging 33：617, 2012

11）West SL, D'Aloisio AA, Agans RP, et al：Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of US women. Arch Intern Med 168：1441-1449, 2008

12）Santoro N, Torrens J, Crawford S, et al：Correlates of circulating androgens in mid-life women：the study of women's health across the nation. J Clin Endocrinol Metab 90：4836-4845, 2005

13）Alarslan D, Sarandol A, Congiz C, et al：Androgens and sexual dysfunction in naturally and surgically menopausal women. J Obstet Gynecol Res 37：1027-1034, 2011

14）Turna B, Apaydin E, Semerci B, et al：Women with low libido：correlation of decreased androgen levels with female sexual function index. Intern J Impotence Res 17：148-153, 2005

15）Davidson BJ, Ross RK, Paganini-Hill A, et al：Total and free estrogens and androgens in postmenopausal women with hip fractures. J Clin Endocrinol Metab 54：115-120, 1982

16）Cummings SR, Browner WS, Bauer DC, et al：Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporosis Fractures Research Group. N Eng J Med 339：733-738, 1998

17）Lambrinoudaki I, Christodoulakos G, Rizos D, et al：Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women. Eur J Endocrinol 154：907-916, 2006

18）Sutton-Tyrrell K, Wildman RP, Matthews KA, et al：Sex hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the study of women across the nation（SWAN）. Circulation 111：1242-1249, 2005

19）Creatsa M, Armeni E, Stamatelopoulos K, et al：Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women. Metabolism 61：193-201, 2011

20）Yasui T, Uemura H, Irahara M, et al：Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women. Clinica Chimica Acta 398：43-47, 2008

21）Berrino F, Muti P, Micheli A, et al：Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst 88：291-296, 1996

22）Rivera-Woll LM, Papalia M, Davis SR, et al：Androgen insufficiency in women：diagnostic and therapeutic implications. Hum Reprod Update 10：421-432, 2004

23）Demers LM：Androgen deficiency in women：role of accurate testosterone measurements. Maturitas 67：39-45, 2010

24）Goldstat R, Briganti E, Tran J, et al：Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 10：390-398, 2003

25）Nappi RE, Albani F, Santamaria V, et al：Menopause and sexual desire：the role of testosterone. Menopause Int 16：162-168, 2010

26）Davis SR, Moreau M, Kroll R, et al：Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 359：2005-2017, 2008

27）Burger HG, Hailes J, Menelaus M, et al：The management of persistent symptoms with estradiol-testosterone implants：clinical, lipid and hormonal results. Maturitas 6：351-358, 1984

28）Somboonporn W, Davis S, Seif M, et al：Testosterone for peri-and postmenopausal women. The Cochrane Database of Systematic Reviews 2005：4［article no：CD004509］.

29）Barrett-Connor E, Young R, Notelovitz M, et al：A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women：effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 44：1012-1020, 1999

30）Tamimi RM, Hankinson SE, Chen WY, et al：Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 166：1483-1489, 2006

31）Braunstein GD：Safety of testosterone treatment in postmenopausal women. Fertil Steril 88：1-17, 2007

32）Shufelt CL and Braunstein GD：Safety of testosterone use in women. Maturitas 63：63-66, 2009