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特集 薬剤投与と泌尿器科的副作用―泌尿器科医の必須知識
文献概要
要旨 薬剤による性機能障害は，QOLに大きな影響を与える。QOLの悪化は，服用コンプライアンスの低下を招き，治療効果の低下や疾患の再発への関与が示唆されている。そのため副作用としての性機能障害の軽減は治療中のQOLの維持のみならず，治療効果の観点からも重要となる。多くの薬剤が性機能障害を引き起こす可能性があるが，代表的な薬剤として，①降圧剤，②抗うつ剤，③男性ホルモン抑制・抗アンドロゲン剤，④α1ブロッカー（射精障害），がある。性機能障害への対策として，①薬剤の中止・変更，②PDE5阻害薬の併用，がある。また性機能への影響を与える可能性の高い薬剤では，治療前・治療中の性機能の問診が重要である。
参考文献
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