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臨床泌尿器科70巻2号

2016年02月発行

特集 ここが知りたい! 筋層非浸潤性膀胱癌─エキスパートが答える日常診療の疑問点

〈診断〉

病理学的分類

著者: 都築豊徳1 前田永子1 村瀬陽太1

所属機関: 1名古屋第二赤十字病院病理診断科

ページ範囲:P.124 - P.131

文献概要

質問 : NMIBCの病理診断におけるgrade分類は2段階分類と3段階分類の併記になっていますが,どちらを使うのがよいのでしょうか? また,特殊なvarient成分が含まれているときにどのような臨床的意義があるでしょうか?

▶ポイント

・尿路上皮癌の異型度分類には2段階方式のWHO/ISUP分類と3段階方式の1973WHO分類の2つがある.米国ではWHO/ISUP分類が,欧州では1973WHO分類が主流である.

・現在ではWHO/ISUP分類に基づく治療方針が一般的であるが,過去のデータの比較には1973WHO分類の併記が必要である.

・筋層非浸潤性膀胱癌において,亜型分類と予後との相関は確立されていない.

参考文献

1) Mostofi FK, Sobin LH and Torloni H : Histological Typing of Urinary Bladder Tumours. p17, World Health Orgnanization, Geneva, 1973
2) Epstein JI, Amin MB, Reuter VR, et al : The World Health Organization/International Society of Urological Pathology consensus classification of urothelial(transitional cell)neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol 22 : 1435─1448, 1998
3) Eble JE, Sauter G, Epstein JI, et al : Pathology and Genetics of Tumour of the Urinary System and Male Genital Organs. pp90─118, Lyon, IRCPress, 2004
4) Network NCC : Bladder Cancer, NCCN Clinical Practice guidelines in oncology(2nd ed), 2015
5) Babjuk M, Burger M, Zigeuner R, et al : EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder : update 2013. Eur Urol 64 : 639─653, 2013
6) Lopez-Beltran A, Algaba F, Berney DM, et al : Handling and reporting of transurethral resection specimens of the bladder in Europe : a web-based survey by the European Network of Uropathology(ENUP). Histopathology 58 : 579─585, 2011
7) 日本泌尿器科学会・日本病理学会・日本放射線学会(編) : 腎盂・尿管・膀胱癌取扱い規約, 金原出版, 東京, 2011
8) Hall MC, Chang SS, Dalbagni G, et al : Guideline for the management of nonmuscle invasive bladder cancer(stages Ta, T1, and Tis) : 2007 update. J Urol 178 : 2314─2330, 2007
9) Amin MB, Smith SC, Reuter VE, et al : Update for the practicing pathologist : The International Consultation On Urologic Disease-European association of urology consultation on bladder cancer. Mod Pathol 28 : 612─630, 2015
10) Drew PA, Furman J, Civantos F, et al : The nested variant of transitional cell carcinoma : an aggressive neoplasm with innocuous histology. Mod Pathol 9 : 989─994, 1996
11) Nigwekar P, Tamboli P, Amin MB, et al : Plasmacytoid urothelial carcinoma : detailed analysis of morphology with clinicopathologic correlation in 17 cases. Am J Surg Pathol 33 : 417─424, 2009
12) Samaratunga H, Delahunt B, Egevad L, et al : Pleomorphic giant cell carcinoma of the urinary bladder : an extreme form of tumour de-differentiation. Histopathology, 2015[Epub ahead of print]
13) MacLennan GT, Kirkali Z and Cheng L : Histologic grading of noninvasive papillary urothelial neoplasms. Eur Urol 51 : 889─897 ; discussion 897─898, 2007
14) Cheng L, MacLennan GT and Lopez-Beltran A : Histologic grading of urothelial carcinoma : a reappraisal. Hum Pathol 43 : 2097─2108, 2012
15) Pan CC, Chang YH, Chen KK, et al : Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder : a clinicopathologic study of 1,515 cases. Am J Clin Pathol 133 : 788─795, 2010
16) Desai S, Lim SD, Jimenez RE, et al : Relationship of cytokeratin 20 and CD44 protein expression with WHO/ISUP grade in pTa and pT1 papillary urothelial neoplasia. Mod Pathol 13 : 1315─1323, 2000
17) Alsheikh A, Mohamedali Z, Jones E, et al : Comparison of the WHO/ISUP classification and cytokeratin 20 expression in predicting the behavior of low-grade papillary urothelial tumors. World/Health Organization/Internattional Society of Urologic Pathology. Mod Pathol 14 : 267─272, 2001
18) Kikuchi E, Fujimoto H, Mizutani Y, et al : Clinical outcome of tumor recurrence for Ta, T1 non-muscle invasive bladder cancer from the data on registered bladder cancer patients in Japan : 1999-2001 report from the Japanese Urological Association. Int J Urol 16 : 279─286, 2009
19) 石田 亮, 都築豊徳, 吉田真理, 他 : Ta膀胱癌における1973年WHO分類とWHO/ISUP分類を用いた臨床病理学的検討. 日本泌尿器科学会誌101 : 609─614, 2010
20) Shah RB, Montgomery JS, Montie JE, et al : Variant(divergent)histologic differentiation in urothelial carcinoma is under-recognized in community practice : impact of mandatory central pathology review at a large referral hospital. Urol Oncol 31 : 1650─1655, 2013
21) Kim SP, Frank I, Cheville JC, et al : The impact of squamous and glandular differentiation on survival after radical cystectomy for urothelial carcinoma. J Urol 188 : 405─409, 2012
22) Mitra AP, Bartsch CC, Bartsch G Jr, et al : Does presence of squamous and glandular differentiation in urothelial carcinoma of the bladder at cystectomy portend poor prognosis? An intensive case-control analysis. Urol Oncol 32 : 117─127, 2014
23) Xylinas E, Rink M, Robinson BD, et al : Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. Eur J Cancer 49 : 1889─1897, 2013
24) Amin MB, Ro JY, el-Sharkawy T, et al : Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol 18 : 1224─1232, 1994
25) Kamat AM, Gee JR, Dinney CP, et al : The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma. J Urol 175 : 881─885, 2006
26) Kamat AM, Dinney CP, Gee JR, et al : Micropapillary bladder cancer : a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients. Cancer 110 : 62─67, 2007
27) Samaratunga H and Khoo K : Micropapillary variant of urothelial carcinoma of the urinary bladder ; a clinicopathological and immunohistochemical study. Histopathology 45 : 55─64, 2004
28) Sangoi AR, Beck AH, Amin MB, et al : Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol 34 : 1367─1376, 2010
29) Spaliviero M, Dalbagni G, Bochner BH, et al : Clinical outcome of patients with T1 micropapillary urothelial carcinoma of the bladder. J Urol 192 : 702─707, 2014
30) Ching CB, Amin MB, Tubbs RR, et al : HER2 gene amplification occurs frequently in the micropapillary variant of urothelial carcinoma : analysis by dual-color in situ hybridization. Mod Pathol 24 : 1111─1119, 2011
31) Schneider SA, Sukov WR, Frank I, et al : Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy : ERBB2(HER2)amplification identifies patients with poor outcome. Mod Pathol 27 : 758─764, 2014
32) Ricardo-Gonzalez RR, Nguyen M, Gokden N, et al : Plasmacytoid carcinoma of the bladder : a urothelial carcinoma variant with a predilection for intraperitoneal spread. J Urol 187 : 852─855, 2012

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1332

印刷版ISSN:0385-2393

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