臨床泌尿器科70巻3号

2016年03月発行

特集 ART時代の男性不妊診療─いま泌尿器科医に求められていること

〈疾患別治療〉

全身疾患と男性不妊

著者： 白石晃司¹

所属機関： ¹山口大学大学院医学系研究科泌尿器科学分野

ページ範囲：P.258 - P.264

文献概要

▶ポイント

・精液所見の異常と生命予後の悪化は関連している．

・男性不妊症患者においては，生活習慣病や悪性腫瘍などの併存疾患の頻度が高くなる．

・精子形成と生活習慣病の発症および発癌は，遺伝子レベルおよび環境因子などが複雑に絡みあっているが，それらの間には共通の病態が存在する可能性がある．

参考文献

1） Honig SC, Lipshultz LI and Jarow J : Significant medical pathology uncovered by a comprehensive male infertility evaluation. Fertil Steril 62 : 1028─1034, 1994

2） Kolettis PN and Sabanegh ES : Significant medical pathology discovered during a male infertility evaluation. J Urol 166 : 178─180, 2001

3） Eisenberg ML, Li S, Behr B, et al : Semen quality, infertility and mortality in the USA. Hum Reprod 29 : 1567─1574, 2014

4）Jensen TK, Jacobsen R, Christensen K, et al : Good semen quality and life expectancy : a cohort study of 43,277 men. Am J Epidemiol 170 : 559─565, 2009

5） Bonde JP, Ernst E, Jensen TK, et al : Relation between semen quality and fertility : a population-based study of 430 first-pregnancy planners. Lancet 352 : 1172─1177, 1998

6） Salonia A, Matloob R, Gallina A, et al : Are infertile men less healthy than fertile men? Results of a prospective case-control survey. Eur Urol 56 : 1025─1031, 2009

7） Eisenberg ML, Li S, Behr B, et al : Relationship between semen production and medical comorbidity. Fertil Steril 103 : 66─71, 2015

8） Sermondade N, Faure C, Fezeu L, et al : BMI in relation to sperm count : an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19 : 221─231, 2013

9） Gaskins AJ, Colaci DS, Mendiola J, et al : Dietary patterns and semen quality in young men. Hum Reprod 27 : 2899─2907, 2012

10） Eisenberg ML, Chen Z, Ye A, et al : Relationship between physical occupational exposures and health on semen quality : data from the Longitudinal Investigation of Fertility and the Environment（LIFE）Study. Fertil Steril 103 : 1271─1277, 2015

11） Schneider G, Kirschner MA, Berkowitz R, et al : Increased estrogen production in obese men. J Clin Endocrinol Metab 48 : 633─638, 1979

12） Stellato RK, Feldman HA, Hamdy O, et al : Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men : prospective results from the Massachusetts male aging study. Diabetes Care 23 : 490─494, 2000

13） Blank DM, Clark RV, Heymsfield SB, et al : Endogenous opioids and hypogonadism in human obesity. Brain Res Bull 34 : 571─574, 1994

14） Winters SJ, Wang C, Abdelrahaman E, et al : Inhibin-B levels in healthy young adult men and prepubertal boys : is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells? J Androl 27 : 560─564, 2006

15） Shafik A and Olfat S : Scrotal lipomatosis. Br J Urol 53 : 50─54, 1981

16） Shiraishi K : Heat and oxidative stress in the germ line. In Agarwal A, Atoken J and Alvarez JG, Studies on Men’s Health and Fertility. pp149─178, Springer, New York, 2012

17） Lotti F, Corona G, Degli Innocenti S, et al : Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples. Andrology 1 : 229─239, 2013

18） Shiraishi K, Shimabukuro T and Naito K : Effects of hemodialysis on testicular volume and oxidative stress in human. J Urol 180 : 644─650, 2008

19） Nguyen RH, Wilcox AJ, Skjaerven R, et al : Men's body mass index and infertility. Hum Reprod 22 : 2488─2493, 2007

20） Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al : Subfecundity in overweight and obese couples. Hum Reprod 22 : 1634─1637, 2007

21） Colaci DS, Afeiche M, Gaskins AJ, et al : Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil Steril 98 : 1193─1199, 2012

22） Bakos HW, Henshaw RC, Mitchell M, et al : Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril 95 : 1700─1704, 2011

23） Raman JD, Nobert CF and Goldstein M : Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis. J Urol 174 : 1819─1822, 2005

24） Walsh TJ, Schembri M, Turek PJ, et al : Increased risk of high-grade prostate cancer among infertile men. Cancer 116 : 2140─2147, 2010

25） Eisenberg ML, Betts P, Herder D, et al : Increased risk of cancer among azoospermic men. Fertil Steril 100 : 681─685, 2013

26） Matzuk MM and Lamb DJ : The biology of infertility : research advances and clinical challenges. Nat Med 14 : 1197─1213, 2008

27） Ji G, Long Y, Zhou Y, et al : Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility. BMC Med 10 : 49, 2012

28） Wei K, Clark AB, Wong E, et al : Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev 17 : 603─614, 2003

29） Ferras C, Zhou XL, Sousa M, et al : DNA mismatch repair gene hMLH3 variants in meiotic arrest. Fertil Steril 88 : 1661─1664, 2007

30） Maduro MR, Casella R, Kim E, et al : Microsatellite instability and defects in mismatch repair proteins : a new aetiology for Sertoli cell-only syndrome. Mol Hum Reprod 9 : 61─68, 2003

31） Skakkebaek NE, Rajpert-De Meyts E and Main KM : Testicular dysgenesis syndrome : an increasingly common developmental disorder with environmental aspects. Hum Reprod 16 : 972─978, 2001