icon fsr

文献詳細

雑誌文献

臨床泌尿器科70巻9号

2016年08月発行

特集 泌尿器科医のための放射線治療学講座─基礎から徹底的に理解する

〈泌尿器科臨床への応用〉

放射線増感

著者: 芝本雄太1

所属機関: 1名古屋市立大学大学院医学研究科放射線医学分野

ページ範囲:P.680 - P.684

文献概要

▶ポイント

・放射線増感の代表は低酸素細胞増感剤であるが,通常分割照射との併用効果は弱く,定位照射などの1回大線量照射との併用が期待される.

・ほかには,低酸素特異的抗腫瘍剤,過酸化水素注入療法,温熱療法,低薬量抗がん剤などがある.

・泌尿器科領域では,膀胱癌に対して低濃度シスプラチンの同時併用が行われるが,大きな腫瘍に対する過酸化水素注入も今後期待できる.

参考文献

1) Shibamoto Y, Nishimoto S, Mi F, et al : Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell-spheroid-solid tumour system. Int J Radiat Biol Relat Stud Phys Chem Med 52 : 347─357, 1987
2) Tsutsui K, Komuro C, Ono K, et al : Chemosensitization by buthionine sulfoximine in vivo. Int J Radiat Oncol Biol Phys 12 : 1183─1186, 1986
3) Shibamoto Y, Sugie C, Ito M, et al : The Japanese experiences with hypoxia-targeting pharmacoradiotherapy : from hypoxic cell sensitisers to radiation-activated prodrugs. Expert Opin Pharmacother 5 : 2459─2467, 2004
4) Shibamoto Y, Yukawa Y, Tsutsui K, et al : Variation in the hypoxic fraction among mouse tumors of different types, sizes and sites. Jpn J Cancer Res 77 : 908─915, 1986
5) Adams GE, Hasan NM and Joiner MC : The Llaas Breur Lecture. Radiation, hypoxia and genetic stimulation : implications for future therapies. Radiother Oncol 44 : 101─109, 1997
6) Shibamoto Y, Nishimoto S, Shimokawa K, et al : Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. Int J Radiat Oncol Biol Phys 16 : 1045─1048, 1989
7) Shibamoto Y, Kubota T, Kishii K, et al : Radiosensitivity of human pancreatic cancer cells in vitro and in vivo, and the effect of a new hypoxic cell sensitizer, doranidazole. Radiother Oncol 56 : 265─270, 2000
8) Shibamoto Y, Sakano K, Kimura R, et al : Radiosensitization in vitro and in vivo by 3-nitrotriazoles. Int J Radiat Oncol Biol Phys 12 : 1063─1066, 1986
9) Shibamoto Y, Ohshio G, Hosotani R, et al : A phase I/II study of a hypoxic cell radiosensitizer KU-2285 in combination with intraoperative radiotherapy. Br J Cancer 76 : 1474─1479, 1997
10) Karasawa K, Sunamura M, Okamoto A, et al : Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer : long-term results of a placebo-controlled randomised study. Radiother Oncol 87 : 326─330, 2008
11) Sealy R : Hyperbaric oxygen in the radiation treatment of head and neck cancers. Radiother Oncol 20 : 75─79, 1991
12) Ogawa Y, Kubota K, Aoyama N, et al : Non-surgical breast-conserving treatment (KORTUC-BCT) using a new radiosensitization method (KORTUC II) for patients with stage I or II breast caner. Cancers 7 : 2277─2289, 2015
13) Shibamoto Y, Zhou L, Hatta H, et al : A novel class of antitumor prodrug, 1- (2'-oxopropyl) -5-fluorouracil (OFU001) that releases 5-fluorouracil upon hypoxic irradiation. Jpn J Cancer Res 91 : 433─438, 2000
14) Shibamoto Y, Tachi Y, Tanabe K, et al : In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation. Int J Radiat Oncol Biol Phys 58 : 397─402, 2004
15) Shibamoto Y, Nishimura Y and Abe M : Intraoperative radiotherapy and hyperthermia for unresectable pancreatic cancer. Hepato gastroenterol 43 : 326─332, 1996
16) Reddy SB and Williamson SK : Tirapazamine : a novel agent targeting hypoxic tumor cells. Expert Opin Investig Drugs 18 : 77─87, 2009
17) Jeremic B, Shibamoto Y, Acimovic L, et al : Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer : a randomized study. J Clin Oncol 14 : 1065─1070, 1996
18) Jeremic B, Shibamoto Y, Stanisavljevic B, et al : Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck : a prospective randomized trial. Radiother Oncol 43 : 29─37, 1997
19) Jeremic B, Shibamoto Y, Acimovic L, et al : Accelerated hyperfractionated radiation therapy and concurrent 5- fluorouracil/cisplatin chemotherapy for locoregional squamous cell carcinoma of the thoracic esophagus : a phase II study. Int J Radiat Oncol Biol Phys 40 : 1061─1066, 1998
20) Mitin T, Hunt D, Shipley WU, et al : Transurethral surgery and twice-daily radiation plus paclitaxel-cisplatin or fluorouracil-cisplatin with selective bladder preservation and adjuvant chemotherapy for patients with muscle invasive bladder cancer (RTOG0233) : a randomized multicentre phase 2 trial. Lancet Oncol 14 : 863─872, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1332

印刷版ISSN:0385-2393

雑誌購入ページに移動
icon up

本サービスは医療関係者に向けた情報提供を目的としております。
一般の方に対する情報提供を目的としたものではない事をご了承ください。
また,本サービスのご利用にあたっては,利用規約およびプライバシーポリシーへの同意が必要です。

※本サービスを使わずにご契約中の電子商品をご利用したい場合はこちら