臨床泌尿器科71巻10号

2017年09月発行

特集 専門医として知っておきたい 性分化疾患の基礎知識

〈基礎と分類〉

性腺の性分化機構

著者： 諸橋憲一郎¹

所属機関： ¹九州大学大学院医学研究院分子生命科学系部門性差生物学分野

ページ範囲：P.746 - P.751

文献概要

▶ポイント

・Y染色体上のSRY遺伝子は性的に未分化な胎児性腺原基（生殖隆起）に一過性に発現し，未分化性腺を精巣へと分化させる．

・性的に未分化な生殖隆起の構築，生殖隆起のオス化，生殖隆起のメス化に必要な遺伝子の変異は，性腺の消失，低形成，精巣─卵巣間での性転換を引き起こす．

・上記の遺伝子には転写関連因子，クロマチン構造制御関連因子，細胞増殖関連因子，シグナル伝達関連因子などが含まれる．

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