臨床泌尿器科72巻6号

2018年05月発行

特集 副腎疾患の基礎と臨床─最前線を知る

〈基礎〉

Ad4BP/SF-1と副腎皮質の発生・副腎性ステロイドの産生

著者： 馬場崇¹

所属機関： ¹九州大学大学院医学研究院分子生命科学系部門性差生物学講座

ページ範囲：P.424 - P.429

文献概要

▶ポイント

・Ad4BP/SF-1は副腎組織の発生，および副腎皮質各層におけるステロイドホルモン産生を統括的に制御する．

・副腎で産生される弱いアンドロゲンは，標的組織で強いアンドロゲンに代謝されてその機能を発揮する．

・近年は，副腎アンドロゲンそのものが生理学的機能を有するとの報告がなされている．

参考文献

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