臨床泌尿器科74巻2号

2020年02月発行

特集 いま話題の低活動膀胱―これを読めば丸わかり！

〈総論〉

低活動膀胱の病態生理―基礎研究からわかってきたこと

著者： 吉村直樹¹

所属機関： ¹ピッツバーグ大学医学部泌尿器科

ページ範囲：P.98 - P.109

文献概要

▶ポイント

・低活動膀胱（UAB）とその背景となる排尿筋低活動（DU）の原因は中枢，末梢の多岐にわたる．

・UAB/DUの誘因として，老化，中枢での神経障害，糖尿病，膀胱出口部閉塞，膀胱虚血，末梢神経傷害に伴う膀胱レベルでの神経性，筋原性の変化が挙げられる．

・UAB/DUの病態解析には，臨床データに基づいた複数の動物モデルによる複合的な研究が必要である．

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