臨床泌尿器科77巻2号

2023年02月発行

特集 徹底解説!　過活動膀胱（OAB）の診療ストラテジー

〈過活動膀胱の発症メカニズム〉

膀胱知覚と尿意切迫感

著者： 相澤直樹¹

所属機関： ¹獨協医科大学医学部薬理学講座

ページ範囲：P.132 - P.137

文献概要

▶ポイント

・膀胱知覚はメカノセンサーや尿路上皮により，緊密に制御されている可能性がある．

・過活動膀胱（OAB）の必須症状である尿意切迫感のみを直接抑制する作用機序をもつ治療オプションは，いまだ存在していない．

・尿意切迫感の発生要因として，排尿筋と尿路上皮にそれぞれ由来する機序が考えられている．

参考文献

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