臨床泌尿器科77巻7号

2023年06月発行

特集 泌尿器病理 鳥瞰図―近未来の泌尿器腫瘍へズームイン

前立腺神経内分泌癌の分類と病理所見

著者： 林博之¹ 河野眞司¹

所属機関： ¹原三信病院病理診断科

ページ範囲：P.526 - P.532

▶ポイント

・前立腺の神経内分泌癌に，小細胞神経内分泌癌，大細胞神経内分泌癌，混合型神経内分泌腫瘍，治療関連前立腺神経内分泌癌がある．

・診断はHE染色による形態学的評価を基本として治療歴を加味し，補助的に免疫染色を用いる．

・神経内分泌腫瘍成分にGleason scoreは適用されない．

参考文献

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2） WHO Classification of Tumours Editorial Board : Urinary and Male Genital Tumours, WHO Classification of Tumours, 5th Edition. International Agency for Research on Cancer, Lyon, 2022

3） 日本泌尿器科学会, 他 （編） : 泌尿器科・病理・放射線科 前立腺癌取扱い規約第5版. メディカルレビュー, 大阪, 2022

4） Moch H, et al : WHO Classification of Tumours of the Urinary System and Male Genital Organs, 4th Edition. International Agency for Research on Cancer, Lyon, 2016

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6） Xin Z, et al : Insulinoma-Associated Protein 1 Is a Novel Sensitive and Specific Marker for Small Cell Carcinoma of the Prostate. Hum Pathol 79 : 151-159, 2018

7） Aggarwal R, et al : Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer : A Multi-institutional Prospective Study. J Clin Oncol 36 : 2492-2503, 2018

8） Epstein JI, et al : AFIP ATLASES OF TUMOR AND NON-TUMOR PATHOLOGY, SERIES 5. Tumors of the Prostate Gland, Seminal Vesicles, Penis, and Scrotum. American Registry of Pathology, Maryland, 2020

9） Williamson SR, et al : ERG-TMPRSS2 Rearrangement Is Shared by Concurrent Prostatic Adenocarcinoma and Prostatic Small Cell Carcinoma and Absent in Small Cell Carcinoma of the Urinary Bladder : Evidence Supporting Monoclonal Origin. Mod Pathol 24 : 1120-1127, 2011

10） Evans AJ, et al : Large Cell Neuroendocrine Carcinoma of Prostate : A Clinicopathologic Summary of 7 Cases of a Rare Manifestation of Advanced Prostate Cancer. Am J Surg Pathol 30 : 684-693, 2006

11） Prendeville S, et al : Prostate Carcinoma with Amphicrine Features : Further Refining the Spectrum of Neuroendocrine Differentiation in Tumours of Primary Prostatic Origin? Histopathology 71 : 926-933, 2017

12） Abdulfatah E, et al : De novo Neuroendocrine Transdifferentiation in Primary Prostate Cancer ― A Phenotype Associated with Advanced Clinico-Pathologic Features and Aggressive Outcome. Med Oncol 38 : 26, 2021

13） Tamas EF, et al : Prognostic Significance of Paneth Cell-Like Neuroendocrine Differentiation in Adenocarcinoma of the Prostate. Am J Surg Pathol 30 : 980-985, 2006