臨床泌尿器科78巻7号

2024年06月発行

特集 キャッチアップ精巣腫瘍―今，知っておくべき進歩 〈トピックス〉

シスプラチン誘発神経毒性の臨床的およびゲノムワイド解析

著者： 上田崇¹ 奥見雅由¹ 浮村理¹

所属機関： ¹京都府立医科大学 泌尿器科学講座

ページ範囲：P.494 - P.499

▶ポイント

・Platinum studyはシスプラチン治療を施行された精巣腫瘍患者における長期的な健康状態を調査し，主に聴神経障害と末梢神経障害の遺伝的要因を探索する目的で設立された．

・シスプラチン誘発神経毒性に関連する遺伝子としてWFS1遺伝子，OTOS遺伝子，RPRD1B遺伝子，FAM20C遺伝子などが報告されている．

・シスプラチンによる神経毒性に関与する非遺伝的要因として，シスプラチン投与量，年齢，喫煙，降圧剤の使用などが挙げられる．

参考文献

1） Gilligan T, et al : Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 17 : 1529-1554, 2019

2） Kerns SL, et al : Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy : A Multi-Institutional Study. J Clin Oncol 36 : 1505-1512, 2018

3） Platinum study　https://cancer.iu.edu/patients/surviving/platinum-study/index.html （2024年4月23日閲覧）

4） Fung C, et al : Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy. J Clin Oncol 35 : 1211-1222, 2017

5） El Charif O, et al : Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms. Clin Cancer Res 25 : 4104-4116, 2019

6） Dolan ME, et al : Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer. Clin Cancer Res 23 : 5757-5768, 2017

7） Trendowski MR, et al : Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors. Clin Cancer Res 26 : 6550-6558, 2020

8） Wheeler HE, et al : Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Clin Cancer Res 23 : 3325-3333, 2017

9） Aaronson NK, et al : The European Organization for Research and Treatment of Cancer QLQ-C30 : a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85 : 365-376, 1993

10） Cella DF, et al : The Functional Assessment of Cancer Therapy scale : development and validation of the general measure. J Clin Oncol 11 : 570-579, 1993

11） Postma TJ, et al : The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy : the QLQ-CIPN20. Eur J Cancer 41 : 1135-1139, 2005

12） Frisina RD, et al : Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer. J Clin Oncol 34 : 2712-2720, 2016

13） Inoue H, et al : A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy （Wolfram syndrome）. Nat Genet 20 : 143-148, 1998

14） Cryns K, et al : Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. Hum Mutat 22 : 275-287, 2003

15） Han BI, et al : Tinnitus : characteristics, causes, mechanisms, and treatments. J Clin Neurol 5 : 11-19, 2009

16） Weidt S, et al : Which tinnitus-related characteristics affect current health-related quality of life and depression? A cross-sectional cohort study. Psychiatry Res 237 : 114-121, 2016

17） Friberg E, et al : Sickness absence due to otoaudiological diagnoses and risk of disability pension : a nationwide Swedish prospective cohort study. PLoS One 7 : e29966, 2012

18） VonaB, et al : Genetics of Tinnitus : Still in its Infancy. Front Neurosci 11 : 236, 2017

19） Zhuo XL, et al : Adenoviral-mediated up-regulation of Otos, a novel specific cochlear gene, decreases cisplatin-induced apoptosis of cultured spiral ligament fibrocytes via MAPK/mitochondrial pathway. Toxicology 248 : 33-38, 2008

20） Ni Z, et al : Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription 2 : 237-242, 2011

21） Morales JC, et al : Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res 42, 4996-5006, 2014

22） Tagliabracci VS, et al : A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell 161 : 1619-1632, 2015

23） Breglio AM, et al : Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun 8 : 1654, 2017