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雑誌文献

臨床外科65巻11号

2010年10月発行

文献概要

特集 外科医のための大腸癌の診断と治療 5.大腸癌の外科治療 ■外科治療総論

直腸癌に対する化学放射線療法と外科治療

著者: 石原聡一郎1 野澤慶次郎1 松田圭二1 渡邉聡明1 井垣浩2

所属機関: 1帝京大学医学部外科 2帝京大学医学部放射線科

ページ範囲:P.206 - P.211

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■化学放射線療法の主たる目的は術後局所再発の減少である.

■術前化学放射線療法の主な適応は治療前T3,4の下部直腸癌である.

■化学放射線療法を終了したのち,6~10週後にTME(TSME)を伴う手術を行う.

参考文献

1)Colorectal Cancer Collaborative Group:Adjuvant radiotherapy for rectal cancer:a systematic overview of 8,507 patients from 22 randomised trials. Lancet 358:1291-1304, 2001
2)Folkesson J, Birgisson H, Pahlman L, et al:Swedish Rectal Cancer Trial:long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 23:5644-5650, 2005
3)Peeters KC, Marijnen CA, Nagtegaal ID, et al:The TME trial after a median follow-up of 6 years:increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246:693-701, 2007
4)Bosset JF, Collette L, Calais G, et al:Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355:1114-1123, 2006
5)Gerard JP, Conroy T, Bonnetain F, et al:Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers:results of FFCD 9203. J Clin Oncol 24:4620-4625, 2006
6)Mohiuddin M, Winter K, Mitchell E, et al:Randomized phase Ⅱ study of neoadjuvant combined-modality chemoradiation for distal rectal cancer:Radiation Therapy Oncology Group Trial 0012. J Clin Oncol 24:650-655, 2006
7)Chau I, Brown G, Cunningham D, et al:Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 24:668-674, 2006
8)Ryan DP, Niedzwiecki D, Hollis D, et al:Phase Ⅰ/Ⅱ study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer:Cancer and Leukemia Group B 89901. J Clin Oncol 24:2557-2562, 2006
9)Rutkowski A, Bujko K, Nowacki MP, et al:Distal bowel surgical margin shorter than 1cm after preoperative radiation for rectal cancer:is it safe? Ann Surg Oncol 15:3124-3131, 2008
10)Sauer R, Becker H, Hohenberger W, et al:Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740, 2004
11)Pettersson D, Cedermark B, Holm T, et al:Interim analysis of the Stockholm Ⅲ trial of preoperative radiotherapy regimens for rectal cancer. Br J Surg 97:580-587, 2010
12)Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al:Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 93:1215-1223, 2006
13)Nagawa H, Muto T, Sunouchi K, et al:Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy. Dis Colon Rectum 44:1274-1280, 2001
14)Kundel Y, Brenner B, Symon Z, et al:A phase Ⅱ study of oral UFT and leucovorin concurrently with pelvic irradiation as neoadjuvant chemoradiation for rectal cancer. Anticancer Res 27:2877-2880, 2007
15)Peeters KC, van de Velde CJ, Leer JW, et al:Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer:increased bowel dysfunction in irradiated patients―a Dutch colorectal cancer group study. J Clin Oncol 23:6199-6206, 2005
16)Pollack J, Holm T, Cedermark B, et al:Long-term effect of preoperative radiation therapy on anorectal function. Dis Colon Rectum 49:345-352, 2006

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

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