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文献詳細

雑誌文献

臨床外科66巻7号

2011年07月発行

文献概要

特集 術前薬物療法は乳癌手術を縮小させるか

術前化学療法とセンチネルリンパ節生検

著者: 井本滋1

所属機関: 1杏林大学医学部外科

ページ範囲:P.882 - P.885

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【ポイント】

◆術前化学療法によって乳房温存率は向上したが,腫瘍とリンパ節転移がpCRとなる効果予測因子とレジメンは明らかではない.

◆術前化学療法後のセンチネルリンパ節生検によるリンパ節郭清の個別化はT1-2N0乳癌では許容される.しかし,T3-4N0乳癌では推奨できない.

◆N+乳癌における術前化学療法とセンチネルリンパ節生検に関する第Ⅱ相臨床試験が行われている.

参考文献

1)Krag DN, Anderson S, Julian TB, et al:Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer:overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 11:927-933, 2010
2)Bear HD, Anderson S, Smith RE, et al:Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 13:2019-2027, 2006
3)von Minckwitz G, Untch M, Nuesch E, et al:Impact of treatment characteristics on response of different breast cancer phenotypes:pooled analysis of the German neo-adjuvant chemotherapy trials. Breast Cancer Res Treat 125:145-156, 2011
4)Lyman GH, Giuliano AE, Somerfield MR, et al:American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23:7703-7720, 2005
5)Weaver DL, Ashikaga T, Krag DN, et al:Effect of occult metastases on survival in node-negative breast cancer. N Engl J Med 364:412-421, 2011
6)Cox CE, Cox JM, White LB, et al:Sentinel node biopsy before neoadjuvant chemotherapy for determining axillary status and treatment prognosis in locally advanced breast cancer. Ann Surg Oncol 13:483-490, 2006
7)Tan VK, Goh BK, Fook-Chong S, et al:The feasibility and accuracy of sentinel lymph node biopsy in clinically node-negative patients after neoadjuvant chemotherapy for breast cancer-A systematic review and meta-analysis. J Surg Oncol, Published online, 2011
8)Shen J, Gilcrease MZ, Babiera GV, et al:Feasibility and accuracy of sentinel lymph node biopsy after preoperative chemotherapy in breast cancer patients with documented axillary metastases. Cancer 109:1255-1263, 2007
9)van Deurzen CHM, de Bore M, Monninkhof EM, et al:Non-sentinel lymph node metastases associated with isolated breast cancer cells in the sentinel node. J Natl Cancer Inst 100:1574-1580, 2008
10)Wada N, Imoto S:Clinical evidence of breast cancer micrometastasis in the era of sentinel node biopsy. Int J Clin Oncol 13:24-32, 2008

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

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