臨床外科67巻11号

2012年10月発行

特集 外科医のための癌診療データ

臓器別最新データ 9．大腸癌

大腸癌の治療

著者： 金光幸秀¹ 小森康司¹ 木村賢哉¹

所属機関： ¹愛知県がんセンター中央病院消化器外科

ページ範囲：P.250 - P.259

文献概要

覚えておきたいデータ

◆「大腸癌取扱い規約」を共通言語にして新たに導入された「大腸癌治療ガイドライン」によって，わが国における大腸癌治療の均てん化が推し進められている．

◆国内医療環境の特徴である，優れた外科手術，病理診断を基礎として，わが国からの良質なエビデンスが出始めている．

◆Stage Ⅳ大腸癌症例の治療成績をいかに向上させるかは，今後の重要な課題である．

参考文献

1）Jemal A, Murray T, Ward E, et al：Cancer statistics, 2005. CA Cancer J Clin 55：10-30, 2005

2）Kotake K, Honjo S, Sugihara K, et al：Changes in colorectal cancer during a 20-year period：an extended report from the multi-institutional registry of large bowel cancer, Japan. Dis Colon Rectum 46（10 Suppl）：S32-43, 2003

3）Coleman MP, Quaresma M, Berrino F, et al；CONCORD Working Group：Cancer survival in five continents：a worldwide population-based study（CONCORD）. Lancet Oncol 9：730-756, 2008

4）OECD Heatlth Care Quality Indicators Data, 2009（www.oecd.org/health/healthpoli-ciesanddata/healthcarequalityindicators.htm）

5）大腸癌研究会（編）：大腸癌治療ガイドライン　医師用　2010年版．金原出版，2010

6）田中信治，工藤進英，鶴田　修：早期大腸癌内視鏡治療ガイドライン．日本消化器内視鏡学会卒後教育委員会（編）；消化器内視鏡ガイドライン第3版．医学書院，2006，pp284-297

7）Tanaka S, Oka S, Kaneko I, Hirata M, et al：Endoscopic submucosal dissection for colorectal neoplasia：possibility of standardization. Gastrointest Endosc 66：100-107, 2007

8）Saito Y, Uraoka T, Yamaguchi Y, et al：A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections（with video）. Gastrointest Endosc 72：1217-1225, 2010

9）Saitoh Y, Watari J, Fujiya M, et al：Endoscopic mucosal resection for flat and depressed type colorectal neoplasia. Techniques in Gastrointestinal Endoscopy 4：42-46, 2002

10）Tanaka S, Tamegai Y, Tsuda S, et al：Multicenter questionnaire survey on the current situation of colorectal endoscopic submucosal dissection in Japan. Dig Endosc 22（Suppl 1）：S2-8, 2010

11）Bipat S, Glas AS, Slors FJ, et al：Rectal cancer：local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis. Radiology 232：773-783, 2004

12）小川真平，板橋道朗，亀岡信悟：ヘリカルCTによる大腸癌リンパ節転移診断．日本大腸肛門病会誌53：35-43，2000

13）萩原信吾，村上康二，藤田昌記，他：FDG-PET．臨放51：1709-1717，2006

14）石黒めぐみ，杉原健一：結腸癌手術における術前・術中のリンパ節転移診断の方法とその有用性．臨外63：367-373，2008

15）Hohenberger P, Du W, Post S：Extended resections for colorectal cancer-indications for supraradical lymphadenectomy. Colorectal Dis 13（Suppl 7）：74-77, 2011

16）渡邉聡明：日本と世界の各種外科疾患における診断・治療戦略の相違．大腸癌―日本と世界の直腸癌治療戦略の相違．日外会誌109：338-342，2008

17）Chang GJ, Rodriguez-Bigas MA, et al：Lymph node evaluation and survival after curative resection of colon cancer：systematic review. J Natl Cancer Inst 99：433-434, 2007

18）Tepper JE, O'Connell MJ, Niedzwiecki D, et al：Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 19：157-163, 2001

19）Kanemitsu Y, Komori K, Ishiguro S, et al：The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection：A Multi-Institutional Study. Ann Surg Oncol 19：2169-2177, 2012

20）Ricciardi R, Baxter NN：Association versus causation versus quality improvement：setting benchmarks for lymph node evaluation in colon cancer. J Natl Cancer Inst 99：414-415, 2007

21）West NP, Morris EJ, Rotimi O, et al：Pathology grading of colon cancer surgical resection and its association with survival：a retrospective observational study. Lancet Oncol 9：857-865, 2008

22）Hohenberger W, Weber K, Matzel K, et al：Standardized surgery for colonic cancer：complete mesocolic excision and central ligation--technical notes and outcome. Colorectal Dis 11：354-364, 2009

23）Heald RJ, Ryall RD：Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 28：1479-1482, 1986

24）日本内視鏡外科学会：内視鏡外科手術に関するアンケート調査―第9回集計結果報告．日鏡外会誌13：499-611，2008

25）Clinical Outcomes of Surgical Therapy Study Group：A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350：2050- 2059, 2004

26）Jayne DG, Guillou PJ, Thorpe H, et al；UK MRC CLASICC Trial Group：Randomized trial of laparoscopic-assisted resection of colorectal carcinoma：3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol 25：3061-3068, 2007

27）Lacy AM, Delgado S, Castells A, et al：The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer. Ann Surg 248：1-7, 2008

28）Buunen M, Veldkamp R, Hop WC, et al；Colon Cancer Laparoscopic or Open Resection Study Group：Survival after laparoscopic surgery versus open surgery for colon cancer：long-term outcome of a randomised clinical trial. Lancet Oncol 10：44-52, 2009

29）Schiessel R, Karner-Hanusch J, Herbst F, et al：Intersphincteric resection for low rectal tumours. Br J Surg 81：1376-1378, 1994

30）ASCRS Symposium on Contaract, IOL and Refractive Surgery, Chicago. April 20-24, 2012

31）固武健二郎，本荘　哲，小山靖夫，大腸癌研究会全国登録委員会：大腸疾患をめぐる最近の話題-腫瘍性病変・大腸癌外科治療の進歩・大腸癌外科治療及び治療成績の変遷・大腸癌研究会全国登録から．カレントテラピー20：720-724，2009

32）Fujita S, Akasu T, Mizusawa J, et al；on behalf of the Colorectal Cancer Study Group of Japan Clinical Oncology Group：Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage Ⅱ or stage Ⅲ lower rectal cancer（JCOG0212）：results from a multicentre, randomised controlled, non-inferiority trial. Lancet Oncol, 2012[in press]

33）Yamamoto S, Inomata M, Kitano S, et al：Short-term clinical outcomes from a randomized controlled trial to evaluate laparoscopic and open surgery for stage Ⅱ-Ⅲ colorectal cancer：Japan Clinical Oncology Group study JCOG 0404（NCT00147134）. J Clin Oncol 30, 2012（suppl 4；abstr 538）

34）André T, Boni C, Mounedji-Boudiaf L, et al：Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer（MOSAIC）Investigators. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350：2343-2351, 2004

35）Kuebler JP, Wieand HS, O'Connell MJ, et al：Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage Ⅱ and Ⅲ colon cancer：results from NSABP C-07. J Clin Oncol 25：2198-2120, 2007

36）Haller DG, Tabernero J, Maroun J, et al：Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage Ⅲ colon cancer. J Clin Oncol 29：1465-1471, 2011

37）Shimada Y, Hamaguchi T, Moriya Y, et al：Randomized phase Ⅲ study of adjuvant chemotherapy with oral uracil and tegafur plus leucovorin versus intravenous fluorouracil and levofolinate in patients（pts） with stage Ⅲ colon cancer（CC）：Final results of Japan Clinical Oncology Group study（JCOG0205）. J Clin Oncol 30, 2012（suppl abstr 3524）

38）Nordlinger B, Sorbye H, Glimelius B, et al；EORTC Gastro-Intestinal Tract Cancer Group：Cancer Research UK；Arbeitsgruppe Lebermetastasen und-tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie（ALM-CAO）；Australasian Gastro-Intestinal Trials Group（AGITG）；Fédération Francophone de Cancérologie Digestive（FFCD）. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer（EORTC Intergroup trial 40983）：a randomised controlled trial. Lancet 22：1007-1016, 2008

39）Kanemitsu Y, Kato T, Shimizu Y et al：A randomized phase Ⅱ/Ⅲ trial comparing hepatectomy followed by mFOLFOX6 with hepatectomy alone as treatment for liver metastasis from colorectal cancer：Japan Clinical Oncology Group Study JCOG0603. Jpn J Clin Oncol 39：406-409, 2009

40）Folkesson J, Birgisson H, Pahlman L, et al：Swedish Rectal Cancer Trial- long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 23：5644-5650, 2005

41）Kapiteijn E, Marijnen CA, Nagtegaal ID, et al；Dutch Colorectal Cancer Group：Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345：638-646, 2001

42）Chau I, Brown G, Cunningham D, et al：Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 24：668-674, 2006

43）Mohiuddin M, Winter K, Mitchell E, et al：Radiation Therapy Oncology Group Trial 0012. Randomized phase Ⅱ study of neoadjuvant combined-modality chemoradiation for distal rectal cancer：Radiation Therapy Oncology Group Trial 0012. J Clin Oncol 24：650-655, 2006

44）Ryan DP, Niedzwiecki D, Hollis D, et al：Phase Ⅰ/Ⅱ study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer：Cancer and Leukemia Group B 89901. J Clin Oncol 24：2557-2562, 2006

45）Sato T, Ozawa H, Hatate K, et al：A Phase Ⅱ trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer：clinical feasibility and response rate. Int J Radiat Oncol Biol Phys 79：677-683, 2011

46）植竹宏之，石川敏昭，石黒めぐみ，他：癌化学療法のエビデンスー大腸癌．消外35：997-1003，2012

47）Tournigand C, André T, Achille E, et al：FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer：a randomized GERCOR study. J Clin Oncol 22：229-237, 2004

48）Hurwitz H, Fehrenbacher L, Novotny W, et al：Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350：2335-2342, 2004