臨床外科67巻12号

2012年11月発行

臨床の疑問に答える「ドクターAのミニレクチャー」・6

グラスゴー予後スコア―血液検査で予後がわかるか

著者： 安達洋祐¹

所属機関： ¹久留米大学医学部外科

ページ範囲：P.1436 - P.1439

文献概要

素朴な疑問

　「グラスゴー予後スコア」（Glasgow prognostic score：GPS）は，血液検査で決まる予後スコアである．がんの予後因子には，腫瘍径・深達度・組織型・脈管侵襲・リンパ節転移・遠隔転移・切除断端・治癒度などがあり，そのために外科医は標本整理や病理診断を大切にしているのに，がん患者の予後が血液検査だけでわかるのだろうか．

参考文献

1）Proctor MJ（UK）：The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters：initial results of the Glasgow Inflammation Outcome Study. Br J Cancer 103：870-876, 2010

2）Proctor MJ（UK）：An inflammation-based prognostic score（mGPS）predicts cancer survival independent of tumour site：a Glasgow Inflammation Outcome Study. Br J Cancer 104：726-734, 2011

3）Procter MJ（UK）：A comparison of inflammation-based prognostic scores in patients with cancer：a Glasgow Inflammation Outcome Study. Eur J Cancer 47：2633-2641, 2011

4）Leitch EF（UK）：Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer 97：1266-1270, 2007

5）Crozier JEM（UK）：Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer. Am J Surg 197：544-549, 2009

6）Roxburgh CSD（UK）：Comparison of tumour-based（Petersen Index）and inflammation-based（Glasgow Prognostic Score）scoring systems in patients undergoing curative resection for colon cancer. Br J Cancer 100：701-706, 2009

7）Moyes LH（UK）：Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer. Br J Cancer 100：1236-1239, 2009

8）Crumley ABC（UK）：Comparison of pre-treatment clinical prognostic factors in patients with gastro-oesophageal cancer and proposal of a new staging system. J Gastrointest Surg 14：781-787, 2010

9）Dutta S（UK）：Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative resection of oesophageal cancer. World J Surg 35：1861-1866, 2011

10）Crumley AB（UK）：Interrelationships between tumor proliferative activity, leucocyte and macrophage infiltration, systemic inflammatory response, and survival in patients selected for potentially curative resection for gastroesophageal cancer. Ann Surg Oncol 18：2604-2612, 2011

11）Dutta（UK）：Comparison of the value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer. Am J Surg, 2012 Mar 21（Epub ahead）

12）Crumley AB（UK）：Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer. Br J Cancer 94：637-641, 2006

13）Glen P（UK）：Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology 6：450-453, 2006

14）Forrest LM（UK）：Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer 89：1028-1030, 2003

15）Al Murri AM（UK）：Evaluation of an inflammation-based prognostic score（GPS）in patients with metastatic breast cancer. Br J Cancer 94：227-230, 2006

16）Ishizuka M（Japan）：Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer. Ann Surg 246：1047-1051, 2007

17）Ishizuka M（Japan）：Influence of inflammation-based prognostic score on mortality of patients undergoing chemotherapy for far advanced or recurrent unresectable colorectal cancer. Ann Surg 250：268-272, 2009

18）Kobayashi T（Japan）：Elevated C-reactive protein and hypoalubuminemia measured before resection of colorectal liver metastases predict postoperative survival. Dig Surg 27：285-290, 2010

19）Kobayashi T（Japan）：Inflammation-based prognostic score, prior to neoadjuvant chemoradiotherapy, predicts postoperative outcome in patients with esophageal squamous cell carcinoma. Surgery 144：729-735, 2008

20）Kobayashi T（Japan）：Inflammation-based prognostic score and number of lymph node metastases are independent prognostic factors in esophageal squamous cell carcinoma. Dig Sarg 27：232-237, 2010

21）Nozoe T（Japan）：Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma. Am J Surg 201：186-191, 2011

22）Ishizuka M（Japan）：Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma：a retrospective study of 398 Japanese patients. Am J Surg 203：101-106, 2012

23）Hashimoto K（Japan）：The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma. Cancer 103：1856-1864, 2005

24）Tei M（Japan）：Risk factors for postoperative delirium in elderly patients with colorectal cancer. Surg Endosc 24：2135-2139, 2010

25）Kanda M（Japan）：Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg 98：268-274, 2011