icon fsr

文献詳細

雑誌文献

臨床外科68巻3号

2013年03月発行

文献概要

特集 CRT時代の直腸癌手術―最善の戦略は何か

直腸癌に対する術前CRTの現況

著者: 清松知充1 渡邉聡明1

所属機関: 1東京大学医学部附属病院腫瘍外科

ページ範囲:P.260 - P.264

文献購入ページに移動
【ポイント】

◆TMEが普及した現在でも,下部進行直腸癌に対する術前CRTは欧米における標準療法である.

◆術前CRTを行うことによって,わが国で行われてきた予防的側方郭清を省略できる可能性がある.

◆術前CRTによって肛門温存率は改善し,奏効例では非手術も今後は選択肢となりうる可能性がある.

参考文献

1)Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 336:980-987, 1997
2)Heald RJ, Ryall RD:Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1:1479-1482, 1986
3)Peeters KC, Marijnen CA, Nagtegaal ID, et al:Dutch Colorectal Cancer Group:The TME trial after a median follow-up of 6 years:increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246:693-701, 2007
4)Bosset JF, Collette L, Calais G, et al:EORTC Radiotherapy Group Trial 22921. Chemoradiotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355:1114-1123, 2006
5)Roh MS, Colangelo LH, O'Connell MJ, et al:Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum:NSABP R03. J Clin Oncol 27:5124-5130, 2009
6)Sauer R, Becker H, Hohenberger W, et al:German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740, 2004
7)Sebag-Montefiore D, Stephens RJ, Steele R, et al:Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer(MRC CR07 and NCIC-CTG C016):A multicentre, randomised trial. Lancet 373:811-820, 2009
8)Holm T, Singnomklao T, Rutqvist LE, et al:Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long term follow-up of two randomized trials. Cancer 78:968-76, 1996
9)Kiyomatsu T, Watanabe T, Muto T, et al:The 4-portal technique decreases adverse effects in preoperative radiotherapy for advanced rectal cancer:comparison between the 2-portal and the 4-portal techniques. Am J Surg 194:542-548, 2007
10)Kusters M, Beets GL, van de Velde CJ, et al:A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg 249:229-235, 2009
11)Sugihara K, Kobayashi H, Kato T, et al:Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum 49:1663-1672, 2006
12)Fujita S, Akasu T, Mizusawa J, et al:Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer(JCOG0212):results from a multicentre, randomised controlled, non-inferiority trial. Lancet Oncol 13:616-621, 2012
13)Akasu T, Sugihara K, Moriya Y, et al:Male urinary and sexual functions after mesorectal excision alone or in combination with extended lateral pelvic lymph node dissection for rectal cancer. Ann Surg Oncol 16:2779-2786, 2009
14)Nagawa H, Muto T, Sunouchi K, et al:Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy. Dis Colon Rectum 44:1274-1280, 2001
15)Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al:Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 93:1215-1223, 2006
16)Sauer R, Fietkau R, Wittekind C, et al:Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer. A progress report of a phase-III randomized trial(protocol CAO/ARO/AIO-94). Strahlenther Onkol 177:173-181, 2001
17)Janjan NA, Khoo VS, Abbruzzese J, et al:Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer:the M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 15:1027-1038, 1999
18)Crane CH, Skibber JM, Feig BW, et al:Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 15:517-524, 2003
19)Watanabe T, Kazama S, Nagawa H:A 1 cm distal bowel margin is safe for rectal cancer after preoperative radiotherapy. Hepatogastroenterology 59:1068-1074, 2012
20)Gavioli M, Luppi G, Losi L, et al:Incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer. Dis Colon Rectum 48:1851-1857, 2005
21)Stipa F, Chessin DB, Shia J, et al:A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography. Ann Surg Oncol 13:1047-1053, 2006
22)Habr-Gama A, Perez RO, Proscurshim I, et al:Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy. J Gastrointest Surg 10:1319-1328, 2006
23)Habr-Gama A, Perez RO, Proscurshim I, et al:Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer:does delayed surgery have an impact on outcome? Int J Radiat Oncol Biol Phys 71:1181-1188, 2008
24)An X, Lin X, Wang FH, et al:Short term results of neoadjuvant chemoradiotherapy with fluoropyrimidine alone or in combination with oxaliplatin in locally advanced rectal cancer:A meta analysis. Eur J Cancer, 2012(Epub ahead of print)
25)Tulchinsky H, Shmueli E, Figer A, et al:An interval>7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer. Ann Surg Oncol 15:2661-2667, 2008

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?