臨床外科68巻4号

2013年04月発行

特集 「食道胃接合部癌」に迫る！

総論

食道胃接合部癌の疫学

著者： 山下裕玄¹ 瀬戸泰之¹

所属機関： ¹東京大学医学部附属病院胃食道外科

ページ範囲：P.395 - P.399

文献概要

【ポイント】

◆わが国において食道胃接合部癌は増加傾向であり，男性に多い．

◆欧米の報告では男性の食道腺癌が急速に増加している．

◆肥満およびGERDは接合部癌の危険因子であると推測される．

参考文献

1）日本食道学会：食道癌取扱い規約 第10版 補訂版．金原出版，2008

2）日本胃癌学会：胃癌取扱い規約 第14版．金原出版，2010

3）Siegel R, Naishadham D, Jemal A：Cancer statistics, 2012. CA Cancer J Clin 62：10-29, 2012

4）Brown LM, Devesa SS, Chow WH：Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst 100：1184-1187, 2008

5）Kazui T, Osada H, Fujita H, et al：Thoracic and cardiovascular surgery in Japan during 2004. Jpn J Thorac Cardiovasc Surg 54：363-385, 2006

6）Kuwano H, Amano J, Yokomise H：Thoracic and cardiovascular surgery in Japan during 2010：annual report by The Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg 60：680-708, 2012

7）Kusano C, Gotoda T, Khor CJ, et al：Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan. J Gastroenterol Hepatol 23：1662-1665, 2008

8）Dikken JL, Lemmens VE, Wouters MW, et al：Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. Eur J Cancer 48：1624-1632, 2012

9）Siewert JR, Stein HJ, Feith M, et al：Histologic tumor type is an independent prognostic parameter in esophageal cancer：lessons from more than 1, 000 consecutive resections at a single center in the Western world. Ann Surg 234：360-367；discussion 368-369, 2001

10）Yamashita H, Katai H, Morita S, et al：Optimal extent of lymph node dissection for Siewert type Ⅱ esophagogastric junction carcinoma. Ann Surg 254：274-280, 2011

11）Fujitani K, Miyashiro I, Mikata S, et al：Pattern of abdominal nodal spread and optimal abdominal lymphadenectomy for advanced Siewert type Ⅱ adenocarcinoma of the cardia：results of a multicenter study. Gastric Cancer, 2012 ［Epub ahead of print］

12）Mine S, Sano T, Hiki N, et al：Lymphadenectomy around the left renal vein in Siewert type Ⅱ adenocarcinoma of the oesophagogastric junction. Br J Surg 100：261-266, 2013

13）Lindblad M, Garcia Rodriguez LA, Chandanos E, et al：Hormone replacement therapy and risks of oesophageal and gastric adenocarcinomas. Br J Cancer 94：136-141, 2006

14）Cronin-Fenton DP, Murray LJ, Whiteman DC, et al：Reproductive and sex hormonal factors and oesophageal and gastric junction adenocarcinoma：a pooled analysis. Eur J Cancer 46：2067-2076, 2010

15）Lagergren J, Jansson C：Sex hormones and oesophageal adenocarcinoma：influence of childbearing? Br J Cancer 93：859-861, 2005

16）Lin Y, Yngve A, Lagergren J, et al：Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes Control 23：837-844, 2012

17）Krotkiewski M, Bjorntorp P, Sjostrom L, et al：Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72：1150-1162, 1983

18）Lagergren J：Influence of obesity on the risk of esophageal disorders. Nat Rev Gastroenterol Hepatol 8：340-347, 2011

19）Lagergren J, Bergstrom R, Nyren O：Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med 130：883-890, 1999

20）Whiteman DC, Sadeghi S, Pandeya N, et al：Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus. Gut 57：173-180, 2008

21）Merry AH, Schouten LJ, Goldbohm RA, et al：Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia：a prospective cohort study. Gut 56：1503-1511, 2007

22）Abnet CC, Freedman ND, Hollenbeck AR, et al：A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur J Cancer 44：465-471, 2008

23）Hoyo C, Cook MB, Kamangar F, et al：Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas：a pooled analysis from the International BEACON Consortium. Int J Epidemiol 41：1706-1718, 2012

24）Akiyama T, Yoneda M, Inamori M, et al：Visceral obesity and the risk of Barrett's esophagus in Japanese patients with non-alcoholic fatty liver disease. BMC Gastroenterol 9：56, 2009

25）Okita K, Amano Y, Takahashi Y, et al：Barrett's esophagus in Japanese patients：its prevalence, form, and elongation. J Gastroenterol 43：928-934, 2008

26）Yamamichi N, Mochizuki S, Asada-Hirayama I, et al：Lifestyle factors affecting gastroesophageal reflux disease symptoms：a cross-sectional study of healthy 19864 adults using FSSG scores. BMC Med 10：45, 2012