文献詳細
文献概要
特集 胃癌腹膜転移治療の最前線
胃癌腹膜転移に対する標準治療とは
著者: 津田享志1 中島貴子1
所属機関: 1聖マリアンナ医科大学臨床腫瘍学
ページ範囲:P.642 - P.646
文献購入ページに移動【ポイント】
◆胃癌腹膜転移例は腹水貯留,腸閉塞,尿管閉塞による水腎症,総胆管閉塞など様々な病態を呈する.
◆軽度から中等度の腹膜転移症例は切除不能進行・再発胃癌の一般的な標準治療(SP療法)を行えることが多い.
◆高度の腹膜転移症例に対しての化学療法は,SP療法などの標準治療ではなく,別途開発が必要である.
◆胃癌腹膜転移例は腹水貯留,腸閉塞,尿管閉塞による水腎症,総胆管閉塞など様々な病態を呈する.
◆軽度から中等度の腹膜転移症例は切除不能進行・再発胃癌の一般的な標準治療(SP療法)を行えることが多い.
◆高度の腹膜転移症例に対しての化学療法は,SP療法などの標準治療ではなく,別途開発が必要である.
参考文献
1)Maehara Y, Hasuda S, Koga T, et al:Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer. Br J Surg 87:353-357, 2000
2)Cunningham D, Starling N, Rao S, et al:Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 358:36-46, 2008
3)Van Cutsem E, Moiseyenko VM, Tjulandin S, et al:Phase Ⅲ study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer:a report of the V325 Study Group. J Clin Oncol 24:4991-4997, 2006
4)Boku N, Yamamoto S, Fukuda H, et al:Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:a randomised phase 3 study. Lancet Oncol 10:1063-1069, 2009
5)Koizumi W, Narahara H, Hara T, et al:S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer(SPIRITS trial):a phase Ⅲ trial. Lancet Oncol 9:215-221, 2008
6)Bang YJ, Van Cutsem E, Feyereislova A, et al:Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer(ToGA):a phase 3, open-label, randomised controlled trial. Lancet 376:687-697, 2010
7)Sakuramoto S, Sasako M, Yamaguchi T, et al:Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357:1810-1820, 2007
8)Nakagawa S, Nnashimoto A, Yabusaki H:Neoadjuvant chemotherapy for patients with positive cytology from advanced gastric cancer. Jpn J Cancer Chemother 33:1774-1776, 2006
9)Shirao K, Boku N, Yamada K, et al:Randomized phaseⅢ study of 5-fluorouracil continuous infusion(5-FUci)versus methotrexate and 5-FU sequential therapy(MF)in gastric cancer with peritoneal metastasis:JCOG 0106. American Society of Clinical Oncology:#4545, 2009
10)Kim WH, Koizumi W, Lee KH, et al:Randomized phaseⅢ study of S-1 alone versus S-1 plus docetaxel in the treatment for advanced gastric cancer. The START trial. ASCO GI symposium San Francisco, CA:#7, 2011
11)Sawaki A, Yamaguchi K, Nabeya Y, et al:5-FU/l-LV(RPMI)vesus S-1 as first-line therapy in patients with advanced gastric cancer. a randmized phaseⅢ non-inferiority trial. (ISO-5FU10 Study Group trial). European Society of Medical Oncology:#509, 2009
12)Takiuchi H, Yasui H, Nishina T, et al:Multicenter feasibility study of 5-FU, leucovorin, plus paclitaxel(FLTAX)for peritoneal disseminated gastric cancer with massive ascites or inadequate oral intake. American Society of Clinical Oncology, Gastrointestinal Cancer Symposium:#119, 2011
13)De Vita F, Orditura M, Matano E, et al:A phaseⅡ study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid(FOLFOX-4)as first-line treatment of advanced gastric cancer patients. Br J Cancer 92:1644-1649, 2005
14)Louvet C, Andre T, Tigaud JM, et al:PhaseⅡ study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol 20:4543-4548, 2002
15)Oh SY, Kwon HC, Seo BG, et al:A phaseⅡ study of oxaliplatin with low dose leucovorin and bolus and continuous infusion 5-fluorouracil(modified FOLFOX-4)as first line therapy for patients with advanced gastric cancer. Acta Oncol 46:336-341, 2007
16)Oh SY, Kwon HC, Lee S, et al:A PhaseⅡ study of oxaliplatin with low-dose leucovorin and bolus and continuous infusion 5-fluorouracil(modified FOLFOX-4)for gastric cancer patients with malignant ascites. Jpn J Clin Oncol 37:930-935, 2007
17)Thuss-Patience PC, Kretzschmar A, Bichev D, et al:Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer―a randomised phaseⅢ study of the Arbeitsgemeinschaft Internistische Onkologie(AIO). Eur J Cancer 47:2306-2314, 2011
18)Kang JH, Lee SI, Lim do H, et al:Salvage chemotherapy for pretreated gastric cancer:a randomized phaseⅢ trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol 30:1513-1518, 2012
19)Arai T, Hamaguchi T, Shirao K, et al:Weekly paclitaxel in patients with heavily treated advanced gastric cancer. American Society of Clinical Oncology:#1291, 2003
20)Hironaka S, Zenda S, Boku N, et al:Weekly paclitaxel as second-line chemotherapy for advanced or recurrent gastric cancer. Gastric Cancer 9:14-18, 2006
21)Ueda S, Hironaka S, Yasui H, et al:Randomized phaseⅢ study of irinotecan(CPT-11)versus weekly paclitaxel(wPTX)for advanced gastric cancer(AGC)refractory to combination chemotherapy(CT)of fluoropyrimidine plus platinum(FP):WJOG4007 trial. American Society of Clinical Oncology:#4002, 2012
22)Takiuchi H, Fukuda H, Boku N, et al:Randmized phaseⅡ study of best-available 5-fluorouracil(5-FU)versus weekly paclitaxel in gastric cancer with peritoneal metastasis(PM)refractory to 5-FU containing regimens:JCOG0407. American Society of Clinical Oncology:#4052, 2010
掲載誌情報