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臨床外科68巻7号

2013年07月発行

臨床の疑問に答える「ドクターAのミニレクチャー」・14

周術期輸血―がん患者の輸血は予後に影響するか

著者: 安達洋祐1

所属機関: 1久留米大学医学部外科

ページ範囲:P.832 - P.835

文献概要

素朴な疑問

 貧血や低栄養がある患者は創離開や縫合不全を起こしやすく,周術期の輸血と栄養補給が重要であるが,輸血を受けた患者は感染防御能や腫瘍免疫力が低下することが知られている.がんの手術が順調に経過するには,貧血や出血を輸血で補正しないといけないが,がん患者に輸血を行うと,感染性合併症や手術死亡,再発や転移が増えたりするのだろうか.

参考文献

1)Donohue JH(USA):Perioperative blood transfusions do not affect disease recurrence of patients undergoing curative resection of colorectal carcinoma:a Mayo/North Central Cancer Treatment Group study. J Clin Oncol 13:1671-1678, 1995
2)Jagoditsch M(Austria):Impact of blood transfusions on recurrence and survival after rectal cancer surgery. Dis Colon Rectum 49:1116-1130, 2006
3)Koch M(Germany):Leukocyte-depleted blood transfusion is an independent predictor of surgical morbidity in patients undergoing elective colon cancer surgery:a single-center analysis of 531 patients. Ann Surg Oncol 18:1404-1411, 2011
4)Froman JP(USA):The impact of an integrated transfusion reduction initiative in patients undergoing resection for colorectal cancer. Am J Surg 2012(Epub of ahead)
5)Heiss MM(Germany):Blood transfusion-modulated tumor recurrence:first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. J Clin Oncol 12:1859-1867, 1994
6)Houbiers JG(Netherlands):Randomised controlled trial comparing transfusion of leukocyte-depleted or buffy-coat-depleted blood in suegery for colorectal cancer. Lancet 344:573-578, 1994
7)van de Watering LM(Netherlands):Perioperative blood transfusions, with or without allogeneic leukocytes, related to survival, not to cancer recurrence. Br J Surg 88:267-272, 2001
8)Jensen LS(Denmark):Randomised comparison of leukocyte-depleted versus buffy-coat-poor transfusion and complications after colorectal surgery. Lancet 348:841-845, 1996
9)Jensen LS(Denmark):Long-term survival after colorectal surgery associated with buffy-coat-poor and leukocyte-depleted blood transfusion:a follow-up study. Lancet 365:681-682, 2005
10)Skanberg J(Sweden):Effects of blood transfusion with leukocyte depletion on length of hospital stay, respiratory assistance and survival after curative surgery for colorectal cancer. Acta Oncol 46:1123-1130, 2007
11)Lange MM(Netherlands):Leukocyte depletion of perioperative blood transfusion does not affect long-term survival and recurrence in patients with gastrointestinal cancer. Br J Surg 96:734-740, 2007
12)Amato A(USA):Perioperative blood transfusion for the recurrence of colorectal cancer. Cochrane Database Syst Rev 25:CD005033, 2006
13)Acheson AG(UK):Effects of allogenic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery. Ann Surg 256:235-244, 2012
14)Al-Refaie WB(USA):Blood transfusion and cancer surgery outcomes:a continued reason for concern. Surgery 152:344-354, 2012
15)Bernard AC(USA):Intraoperative transfusion of 1 U or 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg 208:931-937, 2009
16)Glance LG(USA):Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology 114:283-292, 2011
17)Wu WC(USA):Operative blood loss, blood transfusion, and 30-day mortality in older patients after major noncardiac surgery. Ann Surg 252:11-17, 2010
18)Kooby DA(USA):Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg 237:860-869, 2003
19)Menon KV(UK):Outcomes after major hepatectomy in elderly patients. J Am Coll Surg 203:677-683, 2006
20)Yeh JJ(USA):Effect of transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas. Br J Surg 94:466-472, 2007
21)Rzyman W(Poland):The influence of blood transfusion on survival in operated non-small cell lung cancer patients. J Thorac Cardiovasc Surg 126:755-760, 2003
22)Panagopoulos ND(Greece):Influence of blood transfusions and preoperative anemia on long-term survival in patients operated for non-small cell lung cancer. Lung Cancer 62:273-280, 2008
23)Villanueva C(Spain):Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 368:11-21, 2013
24)Hajjar LA(Brazil):Transfusion requirements after cardiac surgery:the TRACS randomized controlled trial. JAMA 304:1559-1567, 2010
25)Mynster T(Denmark):The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery:Danish RANX05 Colorectal Cancer Study Group. Scand J Gastroenterol 35:212-217, 2000
26)Offner PJ(USA):Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 137:711-716, 2002
27)Leal-Noval SR(Spain):Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology 98:815-822, 2003
28)Mynster T(Denmark):Storage time of transfused blood and disease recurrence after colorectal cancer surgery. Dis Colon Rectum 44:955-964, 2001
29)Edgren G(Sweden):Risk of cancer after blood transfusion from donors with subclinical cancer:a retrospective cohort study. Lancet 369:1724-1730, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

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