icon fsr

文献詳細

雑誌文献

臨床外科69巻1号

2014年01月発行

文献概要

特集 見直される膵癌診療の新展開 治療における新展開―膵癌手術の最前線

膵癌切除後adjuvant chemotherapyの意義

著者: 奈良聡1 小菅智男1 島田和明1 江崎稔1 岸庸二1

所属機関: 1国立がん研究センター中央病院肝胆膵外科

ページ範囲:P.32 - P.36

文献購入ページに移動
【ポイント】

◆RCTの結果,膵癌術後の補助化学療法により,無再発生存期間,全生存期間が延長することが示された.

◆2012年にS-1がゲムシタビンより生存期間を延長することが示され,新たな標準治療として位置付けられた.

◆今後の検討課題として,新規抗癌剤レジメンの開発,術前補助療法との比較などが挙げられる.

参考文献

1)がん情報サービス.一般向け統計情報.最新がん統計(http://ganjoho.jp/public/statistics/pub/)
2)Egawa S, Toma H, Ohigashi H, et al:Japan Pancreatic Cancer Registry;30th Year Anniversary:Japan Pancreas Society. Pancreas 41:985-992, 2012
3)Kosuge T, Kiuchi T, Mukai K, et al:A multicenter randomized controlled trial to evaluate the effect of adjuvant cisplatin and 5-fluorouracil therapy after curative resection in cases of pancreatic cancer. Jpn J Clin Oncol 36:159-165, 2006
4)Ueno H, Kosuge T, Matsuyama Y, et al:A randomised phaseⅢ trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer:Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer 101:908-915, 2009
5)Uesaka K, Fukutomi A, Boku N, et al:Randomized phaseⅢ trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancer(JASPAC-01 study). ASCO Meeting Abstracts 31:145, 2013
6)Kalser MH, Ellenberg SS:Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120:899-903, 1985
7)Bakkevold KE, Arnesjo B, Dahl O, et al:Adjuvant combination chemotherapy(AMF)following radical resection of carcinoma of the pancreas and papilla of Vater―results of a controlled, prospective, randomised multicentre study. Eur J Cancer 29A:698-703, 1993
8)Takada T, Amano H, Yasuda H, et al:Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phaseⅢ multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95:1685-1695, 2002
9)Neoptolemos JP, Stocken DD, Friess H, et al:A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200-1210, 2004
10)Burris HA, 3rd, Moore MJ, Andersen J, et al:Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer:a randomized trial. J Clin Oncol 15:2403-2413, 1997
11)Oettle H, Post S, Neuhaus P, et al:Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer:a randomized controlled trial. JAMA 297:267-277, 2007
12)Oettle H, Neuhaus P, Hochhaus A, et al:Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer:the CONKO-001 randomized trial. JAMA 310:1473-1481, 2013
13)Neoptolemos JP, Stocken DD, Bassi C, et al:Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection:a randomized controlled trial. JAMA 304:1073-1081, 2010
14)Ueno H, Ioka T, Ikeda M, et al:Randomized phaseⅢ study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan:GEST study. J Clin Oncol 31:1640-1648, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?