文献詳細
特集 直腸癌局所再発に対する治療戦略―新たな展開
各論
文献概要
【ポイント】
◆直腸癌局所再発に対する標準化学療法レジメンは確立しておらず,検討されたデータも少ない状況である.
◆直腸癌局所再発に対しては集学的治療が重要であり,化学療法は局所制御のみならず,遠隔転移制御による根治性,延命効果の向上を担っている.
◆直腸癌局所再発に対する標準化学療法レジメンは確立しておらず,検討されたデータも少ない状況である.
◆直腸癌局所再発に対しては集学的治療が重要であり,化学療法は局所制御のみならず,遠隔転移制御による根治性,延命効果の向上を担っている.
参考文献
1)大腸癌研究会(編):大腸癌治療ガイドライン医師用2014年版,金原出版,2014
2)Braendengen M, Tveit KM, Berglund A, et al:Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol 26:3687, 2008
3)Hofheinz RD, Wenz F, Post S, et al:Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer:a randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol 13:579-588, 2012
4)Yong SH, Byung-Ho N, Kyu-Pyo K, et al:Adjuvant chemotherapy with oxaliplatin/5-fluorouracil/leucovorin (FOLFOX) versus 5-fluorouracil/leucovorin (FL) for rectal cancer patients whose postoperative yp stage 2 or 3 after preoperative chemoradiotherapy:Updated results of 3-year disease-free survival from a randomized phase II study (The ADORE). J Clin Oncol 32:5s, 2014 (suppl;abstr 3502)
5)Schrag D, Weiser MR, Goodman KA, et al:Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer:a pilot trial. J Clin Oncol 32:513-518, 2014
6)ClinicalTrials. gov;Neoajuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer(FOWARC)[http://clinicaltrials.gov/ct2/show/study/NCT01211210]
7)ClinicalTrials.gov;Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery [http://clinicaltrials.gov/show/NCT01515787]
8)Douillard JY, Oliner KS, Siena S, et al:Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 369:1023-1034, 2013
9)Folprecht G, Gruenberger T, Bechstein WO, et al:Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab:the CELIM randomised phase 2 trial. Lancet Oncol 11:38-47, 2010
10)Dewdney A, Cunningham D, Barbachano Y, et al:Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin(CAPOX)plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection. Br J Cancer 106:1718-1721, 2012
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