icon fsr

文献詳細

雑誌文献

臨床外科69巻6号

2014年06月発行

文献概要

特集 癌の補助療法アップデート

胆道癌―補助化学療法についての今後の展望

著者: 深瀬耕二1 林洋毅1 片寄友1 海野倫明1

所属機関: 1東北大学病院肝胆膵外科

ページ範囲:P.712 - P.717

文献購入ページに移動
【ポイント】

◆現在,切除不能胆道癌の標準治療はゲムシタビン+シスプラチン(GC)療法である.

◆術前・術後補助化学療法が有用であるというエビデンスはないが,術後補助化学療法の第Ⅲ相無作為比較試験が現在進んでいる.

◆今後の展開として,多剤併用療法の確立や分子標的薬の導入が期待されている.

参考文献

1)Miyakawa S, Ishihara S, Horiguchi A, et al:Biliary tract cancer treatment:5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan. J Hepatobiliary Pancreat Surg 16:1-7, 2009
2)Valle J, Wasan H, Palmer DH, et al:Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362:1273-1281, 2010
3)Glimelius B, Hoffman K, Sjödén PO, et al:Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593-600, 1996
4)Takada T, Nimura Y, Katoh H, et al:Prospective randomized trial of 5-fluorouracil, doxorubicin, and mitomycin C for non-resectable pancreatic and biliary carcinoma:multicenter randomized trial. Hepatogastroenterology 45:2020-2026, 1998
5)Okusaka T, Ishii H, Funakoshi A, et al:Phase Ⅱ study of single-agent gemcitabine in patients with advanced biliary tract cancer. Cancer Chemother Pharmacol 57:647-653, 2006
6)Sharma A, Dwary AD, Mohanti BK, et al:Best supportive care compared with chemotherapy for unresectable gall bladder cancer:a randomized controlled study. J Clin Oncol 28:4581-4586, 2010
7)Okusaka T, Nakachi K, Fukutomi A, et al:Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer:a comparative multicentre study in Japan. Br J Cancer 103:469-74, 2010
8)Furuse J, Okusaka T, Boku N, et al:S-1 monotherapy as first-line treatment in patients with advanced biliary tract cancer:a multicenter phase Ⅱ study. Cancer Chemother Pharmacol 62:849-855, 2008
9)Sasaki T, Isayama H, Nakai Y, et al:A randomized phase Ⅱ study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer. Cancer Chemother Pharmacol 71:973-979, 2013
10)Morizane C, Okusaka T, Mizusawa J, et al:Randomized phase Ⅱ study of gemcitabine plus S-1 versus S-1 in advanced biliary tract cancer:a Japan Clinical Oncology Group trial (JCOG 0805). Cancer Sci 104:1211-1216, 2013
11)Kang MJ, Lee JL, Kim TW, et al:Randomized phase Ⅱ trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma. Acta Oncol 51:860-866, 2012
12)Takada T, Amano H, Yasuda H, et al:Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A Phase Ⅲ multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95:1685-1695, 2002
13)胆道癌診療ガイドライン作成出版委員会:エビデンスに基づいた胆道癌診療ガイドライン.医学図書出版,2007, pp 94-95
14)National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology:Hepatobiliary Cancers version 2. 2013. [http://www.nccn.org/professionals/physician_gls/pdf/hepatobiliary.pdf]
15)Lee J, Park SH, Chang HM, et al:Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer:a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 13:181-188, 2012
16)Malka D, Cervera P, Heurteau-Foulon S, et al:Gemcitabine and oxaliplatin (GEMOX) alone or with cetuximab in first-line treatment of advanced biliary cancers (ABC):Exploratory analyses according to tumor KRAS/BRAF mutations and EGFR expression in a randomized phase Ⅱ trial(BINGO). J Clin Oncol 31, 2013 (suppl;abstr 4127)
17)Bekaii-Saab T, Phelps MA, Li X, et al:Multi-institutional phase Ⅱ study of selumetinib in patients with metastatic biliary cancers. J Clin Oncol 29:2357-2363, 2011

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?