臨床外科69巻9号

2014年09月発行

特集 外科医が知っておくべき小腸疾患

外科医が知っておくべき小腸の生理，機能

著者： 藤森俊二¹ 坂本長逸¹

所属機関： ¹日本医科大学消化器内科学

ページ範囲：P.1042 - P.1047

【ポイント】

◆小腸上皮は広い表面積で腸管内容と接する免疫の最前線である．

◆腸内細菌には消化吸収に役立つ種があるが，小腸における栄養の吸収は多くの場合腸内細菌と競合している．

◆栄養の吸収・腸内細菌・腸管免疫は全身疾患に関与し，注目されている．

参考文献

1）Wright EM, Hirayama BA, Loo DF：Active sugar transport in health and disease. J Intern Med 261：32-43, 2007

2）Baba R, Yamami M, Sakuma Y, et al：Relationship between glucose transporter and changes in the absorptive system in small intestinal absorptive cells during the weaning process. Med Mol Morphol 38：47-53, 2005

3）Karasov WH, Debnam ES：Rapid adaptation of intestinal glucose transport：a brush-border or basolateral phenomenon? Am J Physiol 253：G54-61, 1987

4）Boudry G, David ES, Douard V, et al：Role of intestinal transporters in neonatal nutrition：carbohydrates, proteins, lipids, minerals, and vitamins. J Pediatr Gastroenterol Nutr 51：380-401, 2010

5）Abumrad NA, Davidson NO：Role of the gut in lipid homeostasis. Physiol Rev 92：1061-1085, 2012

6）Betters JL, Yu L：NPC1L1 and cholesterol transport. FEBS Lett 584：2740-2747, 2010

7）Lee-Rueckert M, Blanco-Vaca F, Kovanen PT, et al：The role of the gut in reverse cholesterol transport-focus on the enterocyte. Prog Lipid Res 52：317-328, 2013

8）Aoki Y, Morishita M, Asai K, et al：Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane. Pharm Res 22：1854-1862, 2005

9）Anderle P, Sengstag T, Mutch DM, et al：Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes. BMC Genomics 6：69, 2005

10）Romanato G, Scarpa M, Ruffolo C, et al：Lipid and phospholipid profile after bowel resection for Crohn's disease. Int J Colorectal Dis 23：931-938, 2008

11）Said HM, Mohammed ZM：Intestinal absorption of water-soluble vitamins：an update. Curr Opin Gastroenterol 22：140-146, 2006

12）Burzle M, Hediger MA：Functional and physiological role of vitamin C transporters. Curr Top Membr 70：357-375, 2012

13）Vadlapudi AD, Vadlapatla RK, Mitra AK：Sodium dependent multivitamin transporter（SMVT）：a potential target for drug delivery. Curr Drug Targets 13：994-1003, 2012

14）Alpers DH, Russell-Jones G：Gastric intrinsic factor：the gastric and small intestinal stages of cobalamin absorption. A personal journey. Biochimie 95：989-994, 2013

15）Albert MJ, Mathan VI, Baker SJ：Vitamin B12 synthesis by human small intestinal bacteria. Nature 283：781-782, 1980

16）Hughes CF, Ward M, Hoey L, et al：Vitamin B12 and ageing：current issues and interaction with folate. Ann Clin Biochem 50：315-329, 2013

17）Hao WL, Lee YK：Microflora of the gastrointestinal tract：a review. Methods Mol Biol 268：491-502, 2004

18）Justus PG, McHerron LE, Ward TT：Altered motility and duration of bacterial overgrowth in experimental blind loop syndrome. Dig Dis Sci 29：643-648, 1984