1)Rinke A, Muller HH, Schade-Brittinger C, et al:Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors:a report from the PROMID Study Group. J Clin Oncol 27:4656-4663, 2009
2)Caplin ME, Pavel M, Cwikla JB, et al:Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med 371:224-233, 2014
3)Moertel CG, Lefkopoulo M, Lipsitz S, et al:Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med 326:519-523, 1992
4)Kouvaraki MA, Ajani JA, Hoff P, et al:Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol 22:4762-4771, 2004
5)Sun W, Lipsitz S, Catalano P, et al;Eastern Cooperative Oncology Group:Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumors:Eastern Cooperative Oncology Group Study E1281. J Clin Oncol 23:4897-4904, 2005
6)独立行政法人医薬品医療機器総合機構ホームページ.医療用医薬品の承認審査情報,ザノサー点滴静注用1g審議結果報告書[http://www.info.pmda.go.jp/shinyaku/P201400139/620095000_22600AMX01315_A100_2.pdf]
7)Ramanathan RK, Cnaan A, Hahn RG, et al:Phase II trial of dacarbazine(DTIC)in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282. Ann Oncol 12:1139-1143, 2001
8)Ekeblad S, Sundin A, Janson ET, et al:Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res 13:2986-2991, 2007
9)Strosberg JR, Fine RL, Choi J, et al:First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer 117:268-275, 2011
10)Bukowski RM, Tangen CM, Peterson RF, et al:Phase II trial of dimethyltriazenoimidazole carboxamide in patients with metastatic carcinoid. A Southwest Oncology Group study. Cancer 73:1505-1508, 1994
11)Kulke MH, Stuart K, Enzinger PC, et al:Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24:401-406, 2006
12)Raymond E, Dahan L, Raoul JL, et al:Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364:501-513, 2011
13)Yao JC, Shah MH, Ito T, et al:Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364:514-523, 2011
14)Pavel ME, Hainsworth JD, Baudin E, et al:Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome(RADIANT-2):a randomised, placebo-controlled, phase 3 study. Lancet 378:2005-2012, 2011
15)Ahn HK, Choi JY, Kim KM, et al:Phase II study of pazopanib monotherapy in metastatic gastroenteropancreatic neuroendocrine tumours. Br J Cancer 109:1414-1419, 2013
16)Hobday TJ, Qin R, Reidy-Lagunes D, et al:Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors. J Clin Oncol 2014
17)Pavel M, Baudin E, Couvelard A, et al:ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 95:157-176, 2012
18)Oberg K, Knigge U, Kwekkeboom D, et al:Neuroendocrine gastro-entero-pancreatic tumors:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii124-130, 2012
19)National Comprehensive Cancer Network(NCCN). Neuroendocrine Tumors 2015[http://www.nccn.org]
20)Ramage JK, Ahmed A, Ardill J, et al:Guidelines for the management of gastroenteropancreatic neuroendocrine(including carcinoid)tumours(NETs). Gut 61:6-32, 2012
21)Sorbye H, Welin S, Langer SW, et al:Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma(WHO G3):the NORDIC NEC study. Ann Oncol 24:152-160, 2013
22)Shida T, Kishimoto T, Furuya M, et al:Expression of an activated mammalian target of rapamycin(mTOR)in gastroenteropancreatic neuroendocrine tumors. Cancer Chemother Pharmacol 65:889-893, 2010