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雑誌文献

臨床外科71巻5号

2016年05月発行

文献概要

特集 外科臨床研究のノウハウと重要研究の総まとめ Part2:押さえておきたい外科臨床研究の総まとめ

NET

著者: 増井俊彦1 上本伸二1

所属機関: 1京都大学肝胆膵・移植外科

ページ範囲:P.588 - P.592

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【ポイント】
◆NETは2000年に病態概念の統一が図られた比較的新しい疾患であり,近年分子標的薬の有効性の報告が相次いでいる.
◆膵NET,消化管NETにおいて,機能性,非機能性,および大きさによってリンパ節転移の頻度が異なり,それぞれに応じた切除の範囲が推奨される.
◆肝転移に対する外科的切除術は,非機能性で腫瘍量が少ない場合,および機能性腫瘍の場合,血管内治療に比して良好な生存期間を示す.
◆本邦では全国的なNET登録事業がはじまっており,今後エビデンス構築を進めていく必要がある.

参考文献

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9)樋口哲郎,榎本雅之,杉原健一:大腸カルチノイドのリンパ節転移危険因子.杉原健一,多田正大,藤盛孝博,他(編);大腸疾患NOW2007.日本メディカルセンター,2007,pp 121-128.
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16)Saxena A, Chua TC, Sarkar A, et al:Progression and survival results after radical hepatic metastasectomy of indolent advanced neuroendocrine neoplasms(NENs)supports an aggressive surgical approach. Surgery 149:209-220, 2011
17)Mayo SC, de Jong MC, Bloomston M, et al:Surgery versus intra-arterial therapy for neuroendocrine liver metastasis:a multicenter international analysis. Ann Surg Oncol 18:3657-3665, 2011
18)Rinke A, Muller HH, Schade-Brittinger C, et al:Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors:a report from the PROMID Study Group. J Clin Oncol 27:4656-4663, 2009
19)Caplin ME, Pavel M, Cwikla JB, et al:Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med 371:224-233, 2014
20)Yao JC, Shah MH, Ito T, et al:Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364:514-523, 2011
21)Yao JC, Fazio N, Singh S, et al:Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract(RADIANT-4):a randomised, placebo-controlled, phase 3 study. Lancet 387:968-977, 2016
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23)FROM ECC 2015-neuroendocrine cancer:SSA therapies-(177)Lu-DOTATATE is a better one in NETTER-1. Nat Rev Clin Oncol 12:684, 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

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