1)Vollaard EJ, Clasener HA:Colonization resistance. Antimicrob Agents Chemother 38:409-414, 1994
2)Furusawa Y, Obata Y, Fukuda S, et al:Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446-450, 2013
3)Yin L, Laevsky G, Giardina C:Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity. J Biol Chem 276:44641-44646, 2001
4)Takahashi T, Nakagawa E, Nara T, et al:Effects of orally ingested Bifidobacterium longum on the mucosal IgA response of mice to dietary antigens. Biosci Biotechnol Biochem 62:10-15, 1998
5)Miele L, Valenza V, La Torre G, et al:Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49:1877-1887, 2009
6)Harte AL1, da Silva NF, Creely SJ, et al:Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm(Lond)7:15, 2010
7)Aller R, De Luis DA, Izaola O, et al:Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients:a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 15:1090-1095, 2011
8)Eslamparast T, Poustchi H, Zamani F, et al:Synbiotic supplementation in nonalcoholic fatty liver disease:a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr 99:535-542, 2014
9)Loh G, Blaut M:Role of commensal gut bacteria in inflammatory bowel diseases. Gut Microbes 3:544-555, 2012
10)Atarashi K, Tanoue T, Shima T, et al:Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331:337-341, 2011
11)Peloquin JM, Nguyen DD:The microbiota and inflammatory bowel disease:insights from animal models. Anaerobe 24:102-106, 2013
12)Zocco MA, dal Verme LZ, Cremonini F, et al:Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 23:1567-1574, 2006
13)Tursi A, Brandimarte G, Papa A, et al:Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment:a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 105:2218-2227, 2010
14)Arthur JC, Perez-Chanona E, Mühlbauer M, et al:Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338:120-123, 2012
15)Belcheva A, Irrazabal T, Robertson SJ, et al:Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 158:288-299, 2014
16)Le Leu RK, Hu Y, Brown IL, et al:Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats. Carcinogenesis 31:246-251, 2010
17)Walia S, Kamal R, Kanwar SS, et al:Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats. Nutr Cancer 67:603-611, 2015.
18)Ishikawa H, Akedo I, Otani T, et al:Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int J Cancer 116:762-767, 2005
19)Rafter J, Bennett M, Caderni G, et al:Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85:488-496, 2007
20)Kanazawa H, Nagino M, Kamiya S, et al:Synbiotics reduce postoperative infectious complications:a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbecks Arch Surg 390:104-113, 2005
21)Tanaka K, Yano M, Motoori M, et al:Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy:a prospective randomized controlled trial. Surgery 152:832-842, 2012
22)Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, et al:Benefits of a synbiotic formula(Synbiotic 2000Forte)in critically ill trauma patients:early results of a randomized controlled trial. World J Surg 30:1848-1855, 2006
23)Motoori M, Yano M, Miyata H, et al:Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients. Clin Nutr, 2015. pii:S0261-5614(15)00328-3. doi:10.1016/j.clnu.2015.11.008.