臨床外科73巻13号

2018年12月発行

特集 ここがポイント！—サルコペニアの病態と対処法

総論

サルコペニアの基礎

著者： 小川純人¹

所属機関： ¹東京大学大学院医学系研究科加齢医学

ページ範囲：P.1438 - P.1441

文献概要

【ポイント】
◆高齢者のフレイルの重要な要因，背景としてサルコペニアの存在が知られている．
◆加齢に伴うサイトカインやホルモン動態の変化など，液性因子や免疫・炎症系の加齢性変化がサルコペニアの発症，進展に関与している可能性が明らかになってきている．
◆筋骨連関などサルコペニアと他臓器・組織との連関や，ミトコンドリア機能不全，細胞外マトリックス代謝異常，マイクロRNA，筋肥大関連因子による制御など，臓器連関や病態機序の解明が今後進むと考えられる．

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