臨床外科75巻9号

2020年09月発行

特集 変貌する肝移植—適応拡大・ドナー選択・治療戦略の最先端を知る 肝移植における挑戦

Transplant oncology—難治/高度進行がん治療の未来を拓く

著者： 日比泰造¹

所属機関： ¹熊本大学大学院生命科学研究部小児外科学・移植外科学講座

ページ範囲：P.1110 - P.1115

【ポイント】
◆Transplant oncologyは移植医学と腫瘍学の融合によってがんの診療と研究を発展させる概念である．
◆肝・胆道がんに対する集学的治療に肝移植を統合させることで，生命予後を大きく改善し得る．
◆日本の成熟した高難度肝胆膵外科手術と生体肝移植医療に基づき，概念実証を力強く推進することが期待される．

参考文献

1）Hibi T, Sapisochin G：What is transplant oncology? Surgery 165：281-285, 2019

2）日本消化器外科学会：消化器外科専門医の心得．杏林舎，2020

3）日本肝胆膵外科学会　胆道癌診療ガイドライン作成委員会（編）：エビデンスに基づいた　胆道癌診療ガイドライン　改訂第3版．医学図書出版，2019

4）Rea DJ, Heimbach JK, Rosen CB, et al：Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma. Ann Surg 242：451-458, 2005

5）Darwish Murad S, Kim WR, Harnois DM, et al：Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers. Gastroenterology 143：88-98, 2012

6）Tan EK, Rosen CB, Heimbach JK, et al：Living donor liver transplantation for perihilar cholangiocarcinoma：outcomes and complications. J Am Coll Surg 231：98-110, 2020

7）Ethun CG, Lopez-Aguiar AG, Anderson DJ, et al：Transplantation versus resection for hilar cholangiocarcinoma：an argument for shifting treatment paradigms for resectable disease. Ann Surg 267：797-805, 2018

8）Nagino M：Surgical treatment of perihilar cholangiocarcinoma：resection or transplant? Ann Surg 267：806-807, 2018

9）Rosen CB：Transplantation versus resection for hilar cholangiocarcinoma：an argument for shifting paradigms for resectable disease in annals of surgery 2018. Ann Surg 267：808-809, 2018

10）Bismuth H, Nakache R, Diamond T：Management strategies in resection for hilar cholangiocarcinoma. Ann Surg 215：31-38, 1992

11）Ebata T, Mizuno T, Yokoyama Y, et al：Surgical resection for Bismuth type Ⅳ perihilar cholangiocarcinoma. Br J Surg 105：829-838, 2018

12）Brierley J, Gospodarowicz MK, Wittekind C：TNM classification of malignant tumours. Eighth ed. Oxford, UK；Hoboken, NJ：John Wiley ＆ Sons, Inc, 2017

13）Nagino M, Ebata T, Yokoyama Y, et al：Evolution of surgical treatment for perihilar cholangiocarcinoma：a single-center 34-year review of 574 consecutive resections. Ann Surg 258：129-140, 2013

14）Ebata T, Yokoyama Y, Igami T, et al：Review of hepatopancreatoduodenectomy for biliary cancer：an extended radical approach of Japanese origin. J Hepatobiliary Pancreat Sci 21：550-555, 2014

15）Sapisochin G, Javle M, Lerut J, et al：Liver transplantation for cholangiocarcinoma and mixed hepatocellular cholangiocarcinoma：working group report from the ILTS Transplant Oncology Consensus Conference. Transplantation 104：1125-1130, 2020

16）Hibi T, Kow AWC, Chan A, et al：Current status of liver transplantation in Asia. Int J Surg.（in press）

17）大腸癌研究会：大腸癌治療ガイドライン　医師用　2019年版．金原出版，2019

18）Hagness M, Foss A, Line PD, et al：Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg 257：800-806, 2013

19）Dueland S, Syversveen T, Solheim JM, et al：Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases. Ann Surg 271：212-218, 2020

20）Rosen CB, Nagorney DM, Alberts SR：Is there a role for liver transplantation in the treatment of patients with metastatic colorectal cancer? Ann Surg 271：219-220, 2020

21）Hibi T, Rela M, Eason JD, et al：Liver transplantation for colorectal and neuroendocrine liver metastases and hepatoblastoma. working group report from the ILTS Transplant Oncology Consensus Conference. Transplantation 104：1131-1135, 2020

22）Imai K, Adam R, Baba H：How to increase the resectability of initially unresectable colorectal liver metastases：a surgical perspective. Ann Gastroenterol Surg 3：476-486, 2019

23）Gorgen A, Sapisochin G：Comment on “Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases”：what if those lesions are gone? Ann Surg. 2019 Sep 24［published online ahead of print］

24）Azoulay D, Lim C：Comment on “Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases”：shaking the coconut tree. Ann Surg 271：e122-e124, 2020

25）Dueland S, Line PD：Response to the comment on “Survival following liver transplantation for patients with non-resectable liver only colorectal metastases”：What if those lesions are gone? Ann Surg 271：e124, 2020

26）Tsilimigras DI, Ntanasis-Stathopoulos I, Paredes AZ, et al：Disappearing liver metastases：a systematic review of the current evidence. Surg Oncol 29：7-13, 2019