臨床外科77巻5号

2022年05月発行

特集 直腸癌局所再発に挑む—最新の治療戦略と手術手技

総論

直腸癌局所再発に対する薬物療法

著者： 西村在¹ 山崎健太郎¹

所属機関： ¹静岡県立静岡がんセンター消化器内科

ページ範囲：P.520 - P.523

文献概要

【ポイント】
◆切除可能な直腸癌局所再発に対する標準治療は外科切除である．欧米では周術期治療として術前化学放射線療法（CRT）や術後薬物療法が標準的に行われているが，明確なエビデンスはない．本邦で術前CRTの有用性を検証する第Ⅲ相試験が進行中である．
◆切除不能例であっても腫瘍縮小によりR0切除が期待できる場合には，局所制御効果が期待できるCRTは治療オプションとなり得る．
◆切除不能例に対しては，切除不能大腸癌に準じた全身薬物療法が行われる．

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