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雑誌文献

臨床外科78巻12号

2023年11月発行

特集 胃癌に対するconversion surgery—Stage Ⅳでも治したい!

各論

腹膜播種を有する胃癌に対するconversion surgery

著者: 齋藤心1 山口博紀2 金丸理人1 大澤英之2 高橋和也1 金子勇貴1 倉科憲太郎1 細谷好則1 佐田尚宏1 北山丈二1

所属機関: 1自治医科大学消化器一般外科 2自治医科大学臨床腫瘍科

ページ範囲:P.1349 - P.1355

文献概要

【ポイント】
◆腹膜播種陽性胃癌に対するIp-PTX+SOX療法は,安全で有効な治療である.
◆腹膜播種奏効例に対するconversion surgeryは,予後改善に貢献できる可能性がある.
◆高度腹水を伴う胃癌腹膜播種症例でも,CART併用Ip-PTX+SOX療法により腹水コントロールが期待できる.

参考文献

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3)Yoo CH, Noh SH, Shin DW, et al:Recurrence following curative resection for gastric carcinoma. Br J Surg 87:236-242, 2000
4)Kitayama J, Saito S, Yamaguchi H, et al:ASO author reflections:repeated intraperitoneal paclitaxel with systemic chemotherapy as the first-line treatment for peritoneal malignancy. Ann Surg Oncol 28:3871-3872, 2021
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8)Kinoshita J, Yamaguchi T, Moriyama H, et al:Current status of conversion surgery for stage Ⅳ gastric cancer. Surg Today 51:1736-1754, 2021
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13)Janjigian YY, Shitara K, Moehler M, et al:First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma(CheckMate 649):a randomised, open-label, phase 3 trial. Lancet 398:27-40, 2021
14)Kang YK, Chen LT, Ryu MH, et al:Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer(ATTRACTION-4):a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 23:234-247, 2022
15)Ishigami H, Kitayama J, Kaisaki S, et al:Phase Ⅱ study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis. Ann Oncol 21:67-70, 2010
16)Eiseman JL, Eddington ND, Leslie J, et al:Plasma pharmacokinetics and tissue distribution of paclitaxel in CD2F1 mice. Cancer Chemother Pharmacol 34:465-471, 1994
17)Ohzawa H, Kimura Y, Saito A, et al:Ratios of miRNAs in peritoneal exosomes are useful biomarkers to predict tumor response to intraperitoneal chemotherapy in patients with peritoneal metastases from gastric cancer. Ann Surg Oncol 27:5057-5064, 2020
18)Wei M, Yang T, Chen X, et al:Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells. Oncotarget 8:42262-42271, 2017
19)Yoshida K, Yamaguchi K, Okumura N, et al:Is conversion therapy possible in stage Ⅳ gastric cancer:the proposal of new biological categories of classification. Gastric Cancer 19:329-338, 2016

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1278

印刷版ISSN:0386-9857

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