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雑誌文献

臨床婦人科産科60巻11号

2006年11月発行

文献概要

今月の臨床 エイジングと生殖医療

加齢に伴う男性生殖機能の影響

著者: 岩本晃明1 山川克典1 野澤資亜利1

所属機関: 1聖マリアンナ医科大学泌尿器科

ページ範囲:P.1347 - P.1355

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はじめに

 男性生殖機能は極言すれば高齢になっても亡くなるまで妊孕能を有しているといえる.しかしながら,加齢に伴う生殖器の特徴的な変化としては精巣サイズが小さくなり,硬度・緊満度が低下してくるということがある.男性生殖機能の加齢に伴う影響を論ずるときには加齢による視床下部・下垂体・性腺系への影響を検証しなければならない.そこで本稿では,加齢に伴う内分泌変化,精子数の変化,精巣組織の形態上の変化について解説する.

参考文献

1)Dunn J, Nisula BC, Rodbard D:Transport of steroid hormones:binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53:58-68, 1981
2)Manni A, Pardridge WM, Cefalu W, et al:Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab 61:705-710, 1985
3)Cumming DC, Wall SR:Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism. J Clin Endocrinol Metab 61:873-876, 1985
4)Sparrow D, Bosse R, Rowe JW:The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 51:508-512, 1980
5)Pirke KM, Doerr P:Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Act Endocrinol 80:171-178, 1970
6)Stearns EL, Mcdonnel JA, Kaufman BJ, et al:Declining testicular function with age. Amer L Med 57:761-766, 1974
7)Greenblatt RB, Oettinger M, Bohler CS-S:Estrogen-androgen levels in aging men and women:therapeutic considerations. J Amer Geriat Soc 24:173-178, 1976
8)Levwis JG, Chanadian R, Chisholm GD:Serum 5a-dihydrotestosterone and tesosterone changes with age in man. Acta Endocrinol 82:444-448, 1976
9)Persky H, Smith KD, Basu GK:Relation of psychologic measures of aggression and hostility to testosterone production in man. Psychosom Med 33:265-277, 1971
10)Pirke KM, Doerr P:Age related changes and interrelationships between plasma testosterone, oestradiol and testosterone-binding globulin in normal adult males. Act Endocrinol 74:792-800, 1973
11)Purifoy FE, Koopmans LH, Mayes DM:Age differences in serum androgen levels in normal adult males. Hum Biol 53:499-511, 1981
12)Morley JE, Kaiser FE, Perry HM 3rd, et al:Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 46:410-413, 1997
13)Zmuda JM, Cauley JA, Kriska A, et al:Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. Am J Epidemiol 146:609-617, 1997
14)Harman SM, Metter EJ, Tobin JD, et al:Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86:724-731, 2001
15)岩本晃明,柳瀬敏彦,高栄哲,他:日本人成人男子の総テストステロン,遊離テストステロンの基準値の設定.日本泌尿器科学会雑誌 95:751-760, 2004
16)Johnson L, Petty CS, Porter JC, et al:Germ cell degeneration during postprophase of meiosis and serum concentrations of gonadotropins in young adult and older adult men. Biol Reprod 31:779-784, 1984
17)Bremner WJ, Vitiello MV, Prinz PN:Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 56:1278-1281, 1983
18)Vermeulen A, Kaufmann JM:Role of the hypothalamo-pituitary function in the hypoandrogenism on healthy aging. J Clin Endocrinol Metab 74:704-706, 1992
19)Neaves WB, Johnson L, Porter JC, et al:Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 59:756-763, 1984
20)Mastrogiacomo I, Feghali G, Foresta C, et al:Andropause:incidence and pathogenesis. Arch Androl 9:293-296, 1982
21)福島正人,福田 護,前田雄司,他:造精機能マーカーとしてのインヒビンBの意義,日不妊会誌 47:117-118,2002
22)Bohring C, Krause W:Serum levels of inhibin B in men of different age groups. Aging Male 6:73-78,2003
23)Mahmoud AM, Goemaeres, De Bacquer D, et al:Serum inhibin B levels in community-dwelling elderly men. Clinical Endocrinology 53:141-147, 2000
24)田島政晴:Test Sizeによる睾丸計測.泌尿紀要 34:2013-2020,1988
25)Johnson L, Petty CS, Neaves WB:Influence of age on spermproduction and testicular weights in men. J Reprod Fertil 70:211-218, 1984
26)Kidd SA, Eskenazi B, Wyrobek AJ:Effect of male age on semen quality and fertility:a review of the literature. Fertil Steril 75:237-248, 2001
27)Ng KK, Donat R, Chan L, et al:Sperm output of older men. Human Reproduction 19:1811-1815, 2004
28)Eskenazi B, Wyrobek AJ, Sloter E, et al:The association of age and semen quality in healthy men. Human Reproduction 18:447-454, 2003
29)新田俊一,丹田 均,赤樫圭吾,他:加齢に伴う造精機能の変化についての検討.日本不妊学会誌 37:774,1992
30)厚生労働省大臣官房統計情報部(編):人口動態統計.厚生統計協会,昭和61年
31)厚生労働省大臣官房統計情報部(編):人口動態統計.厚生統計協会,平成16年
32)Rolf C, Behr HM, Nieschlag E:Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19:135-142, 1996
33)Paniagua R, Nistal M, Amat P, et al:Seminiferous tubule involution in elderly men. Biol Reprod 36:939-947, 1987
34)Paniagua R, Martin A, Nistal M, et al:Testicular involution in elderly men:comparison of histologic quantitative studies with hormone patterns. Fertil Steril 47:671-679, 1987
35)Holstein H, Schulze W, Davidoff M:Understanding spermatogenesis is a prerequisite for treatment. Reprod Biol Endocrinol 1:107-122, 2003
36)Kimura M, Itoh N, Takagi S, et al:Balance of apoptosis and proliferation of germ cells related to spermatogenesis in aged men. J Androl 24:185-191, 2003
37)Xi YP, Nette EG, King DW, et al:Age-related changes in normal human basement membrane.Mech Ageing Dev 19:315-324, 1982
38)Johnson L, Petty CS, Neaves WB:Age-related variation in seminiferous tubules in men. A stereologic evaluation. J Androl 7:316-322, 1986
39)Johnson L, Abdo JG, Petty CS, et al:Effect of age on the composition of seminiferous tubular boundary tissue and on the volume of each component in humans. Fertil Steril 49:1045-1051, 1988
40)Kaden R:Testicular histology in the aging man. Fortschr Med 93:1545-1549, 1975
41)Neaves WB, Johnson L, Petty CS:Seminiferous tubules and daily sperm production in older adult men with varied numbers of Leydig cells. Biol Reprod 36:301-308, 1987
42)Kothari LK, Gupta AS:Effect of ageing on the volume, structure and total Leydig cell content of the human testis. Int J Fertil 19:140-146, 1974
43)Dakouane M, Bicchieray L, Bergere M, et al:A histomorphometric and cytogenetic study of testis from men 29-102 years old. Fertil Steril 83:923-892, 2005
44)Paniagua R, Amat P, Nistal M, et al:Ultrastructure of Leydig cells in human ageing testes. J Anat 146:173-183, 1986

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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