臨床婦人科産科60巻9号

2006年09月発行

今月の臨床 PCOS─新たな視点

PCOSの病因

1．インスリン抵抗性

著者： 岩下光利¹

所属機関： ¹杏林大学医学部産科婦人科

ページ範囲：P.1161 - P.1165

文献概要

はじめに

　多嚢胞性卵巣症候群（polycystic ovary syndrome : PCOS）にみられるインスリン抵抗性，すなわち高インスリン血症はPCOSの病態の1つというだけでなく，PCOSの発症そのものに深くかかわっていることが明らかとなってきた．肥満はインスリン抵抗性を伴うが，肥満を合併したPCOSは肥満だけの症例よりインスリン抵抗性が強く，非肥満のPCOSでもインスリン抵抗性がみられる^{1, 2）}．これらのことから，PCOSのインスリン抵抗性はPCOSに本質的な病態であると考えられるようになった．本稿では，インスリン抵抗性からみたPCOSの病態を最近の知見を交えながら解説する．

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