臨床婦人科産科63巻4号

2009年04月発行

今月の臨床 ここが聞きたい―不妊・不育症診療ベストプラクティス II　不妊の治療　C人工授精 【精子凍結保存法】

68.精子性状が不良な場合の精子蘇生率を上げる工夫について教えてください．

著者： 笠井剛¹ 平田修司¹ 星和彦¹

所属機関： ¹山梨大学医学部産婦人科

ページ範囲：P.549 - P.551

[1]はじめに

　ヒトの精子は，哺乳動物のなかで最も凍結・融解に強いといわれているが，凍結によって精子は少なからず損傷を受ける．それには細胞膜の流動性の消失による細胞膜の機能低下，酸化ストレスの影響，DNAのfragmentationの増加，細胞骨格の変化などが関与している．これらの影響の結果，融解精子は運動率や精子運動速度の低下を起こす．

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