icon fsr

文献詳細

雑誌文献

臨床婦人科産科64巻12号

2010年12月発行

文献概要

今月の臨床 子宮体癌診療の動向─これだけは知っておきたい 子宮体癌の診断と治療

5.子宮体癌の術後補助療法

著者: 日浦昌道1 野河孝充1

所属機関: 1国立病院機構四国がんセンター婦人科・臨床研究部

ページ範囲:P.1650 - P.1655

文献購入ページに移動
はじめに

 子宮体癌治療の第一選択は手術療法であり,手術不能例には放射線療法あるいは化学療法が施行される1).再発リスクを有する症例の術後補助療法には化学療法,放射線療法,放射線療法と化学療法の併用があり,いずれの方法を優先するか結論は出ておらず,臨床試験がなされている.わが国では,術後補助療法として放射線療法が施行されてきたが,臨床の場では有害事象の面から最近では化学療法が選択されている.化学療法は進行・再発癌や術後再発が危惧される高リスク群に施行され,本疾患の治療法の評価と臨床試験による標準的治療の確立が課題である.

 本稿では,術後補助療法の現況と今後の方向性について記載したい.

参考文献

1) 日本婦人科腫瘍学会 : 子宮体癌治療ガイドライン,2009年度版.金原出版,2009
2) NCCN Clinical Practice Guidelines in Oncology : Uterine Neoplasms, v.1.2010. http://www.nccn.org/professionals/physician_gls/PDF/uterine.pdf
3) Creutzberg CL, van Putten WLJ, Koper PC, et al : Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma : multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 355 : 1404─1411, 2000
4) Creutzberg CL, van Putten WL, Koper PC, et al : The morbidity of treatment for patients with Stage I endometrial cancer : results from a randomized trial. Int J Radiat Oncol Phys 51 : 1246─1255, 2001
5) Nout RA, SmitVT, Putter H, et al : Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk(PORTEC-2): an open-label, non-inferiority, randomised trial. Lancet 375(9717): 816─823, 2010
6) Keys HM, Roberts JA, Brunetto VL, et al : A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma : a Gynecologic Oncology Group Study. Gynecol Oncol 92 : 744─751, 2004
7) Blake P, Swart AM, Orton J, et al : Adjuvant external beam radiotherapy in the treatment of endometrial cancer(MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet 373 : 137─146, 2009
8) Kong A, Simera I, Collingwood M, et al : Adjuvant radiotherapy for stage I endometrial cancer : systematic review and meta-analysis. Ann Oncol 18 : 1595─1604, 2007
9) Beriwal S, Jain SK, Heron DE, et al : Clinical outcome with adjuvant treatment of endometrial carcinoma using intensity-modulated radiation therapy. Gynecol Oncol 102 : 195─199, 2006
10) Thigpen JT, Buchsbaum HJ, Mangan C, et al : Phase II trial of adriamycin in the treatment of advanced or recurrent endometrial carcinoma : a Gynecologic Oncology Group Study. Cancer Treat Rep 63 : 21─27, 1979
11) Calero F, Asins-Codoñer E, Jimeno J, et al : Epirubicin in advanced endometrial adenocarcinoma : a phase II study of the grupo ginecologico español para el tratamiento oncologico(GGETO).Eur J Cancer 27 : 864─866, 1991
12) Thigpen JT, Blessing JA, Homesley H, et al : Phase II trial of cisplatin as first─line chemotherapy in patients with advanced or recurrent endometrial carcinoma : a Gynecologic Oncology Group Study. Gynecol Oncol 33 : 68─70, 1989
13) Long HJ, Pfeifle DM, Wieand HS, et al : Phase II evaluation of carboplatin in advanced endometrial carcinoma. J Natl Cancer Inst 80 : 276─278, 1988
14) Wadler S, Levy DE, Lincoln ST, et al : Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma : Eastern Cooperative Oncology Group Study E3E93. J Clin Oncol 21 : 2110─2114, 2003
15) Hirai Y, Hasumi K, Onose R, et al : Phase II trial of 3-h infusion of paclitaxel in patients with adenocarcinoma of endometrium : Japanese Multicenter Study Group. Gynecol Oncol 94 : 471─476, 2004
16) Katsumata N, Noda K, Nozawa S, et al : Phase II trial of docetaxel in advanced or metastatic endometrial cancer : a Japanese Cooperative Study. Br J Cancer 93 : 999─1004, 2005
17) Thigpen JT, Blessing JA, DiSaia PJ, et al : A randomized comparison of doxorubicin alone versus doxorubicin plus cyclophosphamide in the management of advanced or recurrent endometrial carcinoma : a Gynecologic Oncology Group Study. J Clin Oncol 12 : 1408─1414, 1994
18) Thigpen JT, Brady MF, Homesley HD, et al : Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma : a Gynecologic Oncology Group Study. J Clin Oncol 22 : 3902─3908, 2004
19) Aapro MS, Wijk FH, Bolis G, et al : Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma : Definitive Results of a Randomised Study(55872)by the EORTC Gynecologic Cancer Group. Ann Oncol 14 : 441─448, 2003
20) Fleming GF, Filiaci VL, Bentley RC, et al : Phase III randomized trial of doxorubicin+cisplatin versus doxorubicin+24─h paclitaxel+filgrastim in endometrial carcinoma : a Gynecologic Oncology Group Study. Ann Oncol 15 : 1173─1178, 2004
21) Fleming GF, Brunetto VL, Cella D, et al : Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma : a Gynecologic Oncology Group Study. J Clin Oncol 22 : 2159─2166, 2004
22) Randall ME, Filiaci VL, Muss H, et al : Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma : a Gynecologic Oncology Group Study. J Clin Oncol 24 : 36─44, 2006
23) Susumu N, Sagae S, Udagawa Y, et al : Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer : A Japanese Gynecologic Oncology Group Study. Gynecol Oncol 108 : 226─233, 2008
24) Homesley HD, Filiaci V, Gibbons SK, et al : A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel : A Gynecologic Oncology Group study. Gynecol Oncol 112 : 543─552, 2009
25) Hiura M, Nogawa T, Matsumoto T, et al : Long-term survival in patients with para-aortic lymph node metastasis with systematic retroperitoneal lymphadenectomy followed by adjuvant chemotherapy in endometrial carcinoma. Int J Gynecol Cancer 20 : 1000─1005, 2010
26) Sovak MA, Dupont J, Hensley ML, et al : Paclitaxel and carboplatin in the treatment of advanced or recurrent endometrial cancer : a large retrospective study. Int J Gynecol Cancer 17 : 197─203, 2007
27) Secord AA, Havrilesky LJ, Camey ME, et al : Weekly low-dose paclitaxel and carboplatin in the treatment of advanced or recurrent cervical and endometrial cancer. Int J Clin Oncol 12 : 31─36, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?