臨床婦人科産科64巻12号

2010年12月発行

今月の臨床 子宮体癌診療の動向─これだけは知っておきたい

最新のトピックス

1．子宮体癌発生の分子機構

著者： 京哲¹

所属機関： ¹金沢大学大学院医学系研究科分子移植学産婦人科

ページ範囲：P.1672 - P.1681

文献概要

はじめに

　子宮内膜癌の発生分子機序は，前癌病変とされる増殖症を経た多段階発癌が推測されるが，大腸癌のように各ステップが分子機構により明確になっているわけではない．ここ10数年の分子生物学的解析の集積によりに内膜癌化にかかわるとされるさまざまな遺伝子異常が同定されてきている．また最近では癌化における癌幹細胞の存在とその役割が注目され，内膜癌でも癌幹細胞の報告がなされている．本稿ではそれらを紹介しながら内膜癌発生の分子機構を浮き彫りにする．

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