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雑誌文献

臨床婦人科産科66巻10号

2012年09月発行

文献概要

今月の臨床 子宮内膜症の薬物療法─薬物特性の理解と個別化治療

新たな治療薬物への展望

著者: 原田竜也1 久保田俊郎1

所属機関: 1東京医科歯科大学大学院生殖機能協関学

ページ範囲:P.871 - P.875

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●現在の子宮内膜症薬物療法は,主としてエストロゲンの低下または拮抗を目的としたホルモン療法であり,薬剤を中止したときの再発率は高い.

●子宮内膜症の組織炎症反応に対する免疫抑制療法やその増殖に必要とされる血管新生に対する抑制剤などが,新たな治療法として考えられている.

●新たなホルモン療法としては,selective progestogen receptor modulatorsやaromatase inhibitorなどがある.

参考文献

1) Struthers RS, Chen T, Bozigian HP, et al : Suppression of serum luteinizing hormone in postmenopausal women by an orally administered nonpeptide antagonist of the gonadotropin-releasing hormone receptor(NBI-42902). J Clin Endocrinol Metab 91 : 3903─3907, 2006
2) Struthers RS, Nicholls AJ, Bozigian HP, et al : Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix. J Clin Endocrinol Metab 94 : 545─551, 2009
3) Miwa K, Hitaka T, Kitazaki T, et al : Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea(TAK-385)as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem 54 : 4998─5012, 2011
4) Kettel LM, Murphy AA, Yen SS, et al : Treatment of endometriosis with the antiprogesterone mifepristone(RU-486). Fertil Steril 65 : 23─28, 1996
5) Chwalisz K, Perez MC, Elger W, et al : Selective progesterone receptor modulator development and use in the treatment of leiomyoma and endometriosis. Endocr Rev 26 : 423─438, 2005
6) Donnez J, Tomaszewski J, Loumaye E, et al : PEARL II Study Group. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 366 : 421─432, 2012
7) Takayama K, Zeitoun K, Bulun SE, et al : Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil Steril 69 : 709─713, 1998
8) Ailawadi RK, Jobanputra S, BulunSE, et al : Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate : a pilot study. Fertil Steril 81 : 290─296, 2004
9) Soysal S, Soysal ME, Gezgin T, et al : The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis : a prospective randomized trial. Hum Reprod 19 : 160─167, 2004
10) McKinnon B, Bersinger NA, Mueller MD, et al : PPAR-γ expression in peritoneal endometriotic lesions correlates with pain experienced by patients. Fertil Steril 93 : 293─296, 2010
11) Lebovic DI, Mwenda JM, D'Hooghe T, et al : Peroxisome proliferator-activated receptor-(gamma)receptor ligand partially prevents the development of endometrial explants in baboons : a prospective, randomized, placebo-controlled study. Endocr 151 : 1846─1852, 2010
12) Scholl B, Bersinger NA, Mueller MD, et al : Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis. Gynecol Endocrinol 25 : 701─706, 2009
13) Barrier BF, Bates GW, Propst AM, et al : Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons. Fertil Steril 81 : 775─779, 2004
14) Koninckx PR, Craessaerts M, Kennedy S, et al : Anti-TNF-alpha treatment for deep endometriosis-associated pain : a randomized placebo-controlled trial. Hum Reprod 23 : 2017─2023, 2008
15) Asano T, Kume H, Hasegawa Y, et al : Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma. Biol Pharm Bull 33 : 1028─1032, 2010
16) Becker CM, Sampson DA, D'Amato RJ, et al : Endostatin inhibits the growth of endometriotic lesions but does not affect fertility. Fertil Steril 84 : 1144─1155, 2005

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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