臨床婦人科産科66巻11号

2012年10月発行

今月の臨床 ホルモン補充療法ガイドライン2012年度版─改訂版を読み解く HRTに期待される作用・効果

4．血管機能・血圧に対する作用

著者： 河野宏明¹

所属機関： ¹熊本大学医学部附属病院

ページ範囲：P.949 - P.955

●虚血性心疾患に代表される心血管系疾患は，男性のほうが多いが，女性は閉経後に増加する．

●エストロゲンは内皮からのnitric oxide産生を増加させることで血管を拡張し動脈硬化進展を抑制することが知られている．しかしながら，ホルモン補充療法は急性心筋梗塞の一次，および二次予防効果がなかったことが報告されている．

●エストロゲンのユニークな血管への作用機序を解明することは，動脈硬化性疾患に対する新たな展開を導き出す可能性があると思われる．

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