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雑誌文献

臨床婦人科産科66巻3号

2012年03月発行

文献概要

今月の臨床 不育症の診療指針

不育症に関する遺伝的要因

著者: 杉浦真弓1 水谷栄太1 北折珠央1

所属機関: 1名古屋市立大学大学院医学研究科

ページ範囲:P.232 - P.239

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●不育症の原因は夫婦染色体異常,子宮奇形,抗リン脂質抗体である.

●胎児染色体異常も51%を占め,真の原因不明は約20%と推定できる.

●均衡型転座保因者に対する着床前診断の自然妊娠に対する優位性は立証されていない.

●双角子宮,中隔子宮に対する手術の有効性は確立されていない.

参考文献

1) Sugiura-Ogasawara M, Ozaki Y, Sato T, et al : Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 81 : 367─373, 2004
2) Franssern MTM, Korevaar JC, van der Veen F,et al : Reproductive outcome after chromosome analysis in couples with two or more miscarriages : case-control study. BMJ 332 : 759─762, 2006
3) Sugiura-Ogasawara M, Ozaki Y, Kitaori T, et al : Midline uterine defect size correlated with miscarriage of euploid embryos in recurrent cases. Fertil Steril 93 : 1983─1988, 2010
4) Ogasawara M, Aoki K, Okada S, et al : Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 73 : 300─304, 2000
5) Bolor H, Mori T, Nishiyama S, et al : Mutations of the SYCP3 gene in women with recurrent pregnancy loss. Am J Hum Genet 84 : 14─20, 2009
6) Mizutani E, Suzumori N, Ozaki Y, et al : SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy. Hum Reprod 26 : 1259─1266, 2011
7) Makino A, Nakanishi T, Sugiura-Ogasawara M, et al : No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss. Am J Reprod Immunol 52 : 60─66, 2004
8) Ogasawara MS, Aoki K, Katano K, et al : Factor XII but not protein C, protein S, antithrombin III or factor XIII as a predictor of recurrent miscarriage. Fertil Steril 75 : 916─919, 2001
9) Rey E, Kahn SR, David M, et al : Thromboplilic disorders and fetal loss : a meta-analysis. Lancet 361 : 901─908, 2003
10) Iinuma Y, Sugiura-Ogasawara M, Makino A, et al : Coagulation factor XII activity, but not an associated common genetic polymorphism(46C/T), is linked to reccurent miscarriages. Fertil Steril 77 : 353─356, 2001
11) Sotiriadis A, Makrigiannakis A, Stefos T, et al : Fibrinolytic defects and recurrent miscarriage. Obstet Gynecol 109 : 1146─1155, 2007
12) Sugiura-Ogasawara M, Ozaki Y, Nakanishi T, et al : Occasional antiphospholipid antibody positive patients with recurrent pregnancy loss also merit aspirin therapy : A retrospective cohort-control study. Am J Reprod Immunol 59 : 235─241, 2008
13) Sugiura-Ogasawara M, Ozaki Y, Kitaori T, et al : Live birth rate according to maternal age and previous number of recurrent miscarriages. Am J Reprod Immunol 62 : 314─319, 2009
14) Kaandorp SP, Goddijn M, van der Post JAM, et al : Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 362 : 1586─1596, 2010
15) Ata B, Tan SL, Shehata F, et al : A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage. Fertil Steril 95 : 1080─1085, 2011
16) Branch DW, Gibson MG, Silver RM : Recurrent miscarriage. N Engl J Med 360 : 1740─1747, 2010

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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