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雑誌文献

臨床婦人科産科67巻8号

2013年08月発行

文献概要

今月の臨床 婦人科がんの予防戦略と早期診断 子宮頸がん

4.新たなHPVワクチンの開発

著者: 川名敬1

所属機関: 1東京大学大学院医学系研究科産科婦人科学講座

ページ範囲:P.790 - P.797

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●子宮頸がんの予防効果を高めるための次世代のHPVワクチンの開発が進んでいる.

●HPVを標的にした細胞性免疫を誘導する免疫療法が期待される.

●CIN2~3に対する治療薬としてE7標的がんワクチンを開発中である.

参考文献

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2) Villa LL, Costa RL, Petta CA, et al : High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up. Br J Cancer 95 : 1459─1466, 2006
3) Muñoz N, Manalastas R Jr, Pitisuttithum P, et al : Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus(types 6, 11, 16, 18) recombinant vaccine in women aged 24-45 years : a randomised, double-blind trial. Lancet 373 : 1949─1957, 2009
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15) Broad Spectrum HPV Vaccine Study(V503-001)in 16-to 26-Year-Old Women, Clinical Trials. Gov, U.S. National Institutes of Health, http://clinicaltrials.gov/ct2/show/study/NCT00543543?term=HPV+V503&rank=1&show_locs=Y#locn
16) Nakagawa M, Stites DP, Farhat S, et al : Cytotoxic T lymphocyte responses to E6 and E7 proteins of human papillomavirus type 16 : Relationship to cervical intraepithelial neoplasia. J Infect Dis 175 : 927, 1997
17) Ressler S, Scheiden R, Dreier K, et al : High-risk human papillomavirus E7 oncoprotein detection in cervical squamous cell carcinoma. Clin Cancer Res 13 : 7067─7072, 2007
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掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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