icon fsr

文献詳細

雑誌文献

臨床婦人科産科68巻12号

2014年12月発行

文献概要

今月の臨床 子宮内膜症治療の未来図 発症機序からみた予防・治療戦略

3.エピジェネティクス異常からみた子宮内膜症の治療戦略

著者: 奈須家栄12 甲斐健太郎1 楢原久司1

所属機関: 1大分大学医学部産科婦人科 2大分大学医学部地域医療支援システム・産婦人科分野

ページ範囲:P.1164 - P.1169

文献購入ページに移動
●子宮内膜症に特徴的な形質の獲得にはエピジェネティクス異常が関与しており,病因として注目されている.

●マイクロアレイを用いた網羅的解析法により,子宮内膜症におけるエピジェネティクス異常が徐々に解明されている.

●子宮内膜症の治療薬として,エピジェネティクス異常の修正を目的とする薬物の開発が期待されている.

参考文献

1) Giudice LC, et al : Endometriosis. Lancet 364 : 1789─1799, 2004
2) Practice Committee of the American Society for Reproductive Medicine : Endometriosis and infertility. Fertil Steril 81 : 1441─1446, 2004
3) Farquhar CM : Extracts from the “clinical evidence”. Endometriosis. BMJ 32 : 1449─1452, 2000
4) Kokura K, et al : The Ski protein family is required for MeCP2-mediated transcriptional repression. J Biol Chem 276 : 34115─34121, 2001
5) Jones PA, et al : The fundamental role of epigenetic events in cancer. Nat Rev Genet 3 : 415─428, 2002
6) Ehrlich M : Expression of various genes is controlled by DNA methylation during mammalian development. J Cell Biochem 88 : 899─910, 2003
7) Bogdanovic O, et al : DNA methylation and methyl-CpG binding proteins : developmental requirements and function. Chromosoma 118 : 549─565, 2009
8) Reik W, et al : Epigenetic reprogramming in mammalian development. Science 293 : 1089─1093, 2001
9) Robertson KD, et al : DNA methylation in health and disease. Nat Rev Genet 1 : 11─19, 2000
10) Ting AH, et al : Mammalian DNA methyltransferase 1 : inspiration for new directions. Cell Cycle 3 : 1024─1026, 2004
11) Hendrich B, et al : The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet 19 : 269─277, 2003
12) Wu Y, et al : Promoter hypermethylation of progesterone receptor isoform B(PR-B)in endometriosis. Epigenetics 1 : 106─111, 2006
13) Wu Y, et al : Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. Reprod Sci 14 : 374─382, 2007
14) Wu Y, et al : Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol 193 : 371─380, 2005
15) Xue Q, et al : Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis. Biol Reprod 77 : 681─687, 2007
16) Xue Q, et al : Transcriptional Activation of steroidogenic factor-1 by hypomethylation of the 5’ CpG island in endometriosis. J Clin Endocrinol Metab 92 : 3261─3267, 2007
17) Izawa M, et al : An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells. Fertil Steril 89 : 1390─1396, 2008
18) Izawa M, et al : Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues. Fertil Steril 95 : 33─39, 2011
19) Abe W, et al : miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells. Hum Reprod 28 : 750─761, 2013
20) Robertson KD : DNA methylation and human disease. Nat Rev Genet 6 : 597─610, 2005
21) Wu Y, et al : Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Fertil Steril 87 : 24─32, 2007
22) Yoo CB, et al : Epigenetic therapy of cancer : past, present and future. Nat Rev Drug Discov 5 : 37─50, 2006
23) Egger G, et al : Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 : 457─463, 2004
24) Brena RM, et al : Quantitative assessment of DNA methylation : potential applications for disease diagnosis, classification, and prognosis in clinical settings, J Mol Med 84 : 365─377, 2006
25) Esteller M : Epigenetics in cancer. N Engl J Med 358 : 1148─1159, 2008
26) Foubister V : Drug reactivates genes to inhibit cancer. Drug Discov Today 8 : 430─431, 2003
27) Scott GK, et al : Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 66 : 1277─1281, 2006
28) Lin X, et al : Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase(GSTP1)expression in human prostate cancer cells by treatment with procainamide. Cancer Res 61 : 8611─8616, 2001
29) Noguchi M, et al : Inhibitory effect of the tea polyphenol,(−)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines. Cancer Lett 234 : 135─142, 2006
30) Davis AJ, et al : Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest New Drugs 21 : 85─97, 2003
31) Korkmaz A, et al : Epigenetic regulation : a new research area for melatonin? J Pineal Res 44 : 41─44, 2007
32) Flynn J, et al : A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. J Biol Chem 278 : 8238─8243, 2003
33) Mai A, et al : Histone deacetylation in epigenetics : an attractive target for anticancer therapy. Med Res Rev 25 : 261─309, 2005
34) Kawano Y, et al : Application of the histone deacetylase inhibitors for the treatment of endometriosis : histone modifications as pathogenesis and novel therapeutic target. Hum Reprod 26 : 2486─2498, 2011
35) Imesch P, et al : Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells. Fertil Steril 100 : 770─776, 2013
36) Monteiro JB, et al : Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci 21 : 305─318, 2014
37) Imesch P, et al : Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells. Fertil Steril 94 : 2838─2842, 2010
38) Kawano Y, et al : CCAAT/enhancer-binding protein α is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. J Clin Endocrinol Metab 98 : E1474─E1482, 2013
39) Kai K, et al : Death Receptor 6 is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis. Am J Reprod Immunol 70 : 485─496, 2013
40) Wu Y, et al : Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol 137 : 198─203, 2008
41) Wu Y, et al : Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol 137 : 198─203, 2008
42) Wu Y, et al : Prolonged stimulation with tumor necrosis factor-α induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells. Fertil Steril 90 : 234─237, 2008
43) Wu Y, et al : Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells. Fertil Steril 91(Suppl) : 2142─2147, 2009
44) Lu Y, et al : Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. Hum Reprod 25 : 1014─1025, 2010
45) Liu M, et al : Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats. Reprod Sci 19 : 360─373, 2012
46) Liu X, et al : A pilot study on the off-label use of valproic acid to treat adenomyosis. Fertil Steril 89 : 246─250, 2008

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?