文献詳細
今月の臨床 メタボとロコモ―これからの女性医療のキーワード
女性のメタボリック症候群
文献概要
●女性は40歳頃から年齢とともに肥満者の割合が増加する.
●閉経後は,メタボリック症候群に関与する内臓脂肪の蓄積が増加する.
●肥満は,子宮内膜がん,乳がん発生のリスク因子の1つである.
●閉経後は,メタボリック症候群に関与する内臓脂肪の蓄積が増加する.
●肥満は,子宮内膜がん,乳がん発生のリスク因子の1つである.
参考文献
1) 平成23年国民健康・栄養調査結果の概要(厚生労働省)http://www.mhlw.go.jp/stf/houdou/2r9852000002q1st-att/2r9852000002q1wo.pdf
2) Trémollieres FA, Pouilles JM, Ribot CA : Relative influence of age and menopause on total and regional body composition changes in postmenopausal women. Am J Obstet Gynecol 175 : 1594-1600, 1996
3) Kotani K, Tokunaga K, Fujioka S, et al : Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. Int J Obes Relat Metab Disord 18 : 207-212, 1994
4) Yamatani H, Takahashi K, Yoshida T, et al : Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women. Menopause 20 : 437-442, 2013
5) Kissebah A, Vydelingum N, Murray R, et al : Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 54 : 254-260, 1982
6) Fujioka S, Matsuzawa Y, Tokunaga K, et al : Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36 : 54-59, 1987
7) Maeda K, Okubo K, Shimomura I, et al : cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1(AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221 : 286-289, 1996
8) Kondo H, Shimomura I, Matsukawa Y, et al : Association of adiponectin mutation with type 2 diabetes : a candidate gene for the insulin resistance syndrome. Diabetes 51 : 2325-2328, 2002
9) Ouchi N, Kihara S, Arita Y, et al : Novel modulator for endothelial adhesion molecules : adipocyte-derived plasma protein adiponectin. Circulation 100 : 2473-2476, 1999
10) Ouchi N, Kihara S, Arita Y, et al : Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103 : 1057-1063, 2001
11) Arita Y, Kihara S, Ouchi N, et al : Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105 : 2893-2898, 2002
12) Rexrode KM, Carey VJ, Hennekens CH, et al : Abdominal adiposity and coronary heart disease in women. JAMA 280 : 1843-1848, 1998
13) Dow CA, Thomson CA, Flatt SW, et al : Predictors of improvement in cardiometabolic risk factors with weight loss in women. J Am Heart Assoc 2 : e000152, 2013
14) Huang AJ, Subak LL, Wing R, et al : An intensive behavioral weight loss intervention and hot flushes in women. Arch Intern Med 170 : 1161-1167, 2010
15) Compston JE, Watts NB, Chapurlat R, et al : Obesity is not protective against fracture in postmenopausal women : GLOW. Am J Med 124 : 1043-1050, 2011
16) Kaaks R, Lukanova A, Kurzer MS : Obesity, endogenous hormones, and endometrial cancer risk : a synthetic review. Cancer Epidemiol Biomarkers Prev 11 : 1531-1543, 2002
17) Esposito K, Chiodini P, Colao A, et al : Metabolic syndrome and risk of cancer : a systematic review and meta-analysis. Diabetes Care 35 : 2402-2411, 2012
掲載誌情報