臨床婦人科産科68巻9号

2014年09月発行

今月の臨床 いま注目されている　早発卵巣不全（POI）

POIとゴナドトロピン異常

著者： 髙橋健太郎¹

所属機関： ¹滋賀医科大学地域周産期医療学講座

ページ範囲：P.867 - P.875

文献概要

●POIは必ずしも卵子の枯渇による不可逆的な卵巣機能を意味するものではなく，決して稀な疾患ではない．

●近年，遺伝子解析の進歩によりPOIの病因となるゴナドトロピンおよびその受容体遺伝子異常が発見されつつある．

●変異LHの生物活性は人種差が強く，異常を示さないものもあるが，本邦婦人ではPOIとの関連性が疑われる．

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