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雑誌文献

臨床婦人科産科69巻1号

2015年01月発行

今月の臨床 ゲノム時代の婦人科がん診療を展望する─がんの個性に応じたpersonalizationへの道

【各論1】子宮頸がん

3.子宮頸がんに対する同時化学放射線療法の今後

著者: 戸板孝文1 粕谷吾朗1 有賀拓郎1

所属機関: 1琉球大学大学院医学研究科放射線診断治療学

ページ範囲:P.59 - P.62

文献概要

●同時併用薬剤の強化とともに遠隔転移予防を主眼とした抗がん剤の継時的(sequential)投与が注目されている.

●ベバシズマブなどの分子標的薬追加による効果が期待されている.

●CCRTの主治療である放射線治療の最適化は最も重要な課題である.

参考文献

1) Toita T, et al : Cervical Cancer(Vulva Cancer) Committee of Japanese Gynecologic Oncology Group(JGOG) : Phase II study of concurrent chemoradiotherapy with high-dose-rate intracavitary brachytherapy in patients with locally advanced uterine cervical cancer : efficacy and toxicity of a low cumulative radiation dose schedule. Gynecol Oncol 126 : 211─216, 2012
2) DiSilvestro PA, et al : Gynecologic Oncology Group. Radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in cervical carcinoma limited to the pelvis : a phase I/II study of the Gynecologic Oncology Group. Gynecol Oncol 103 : 1038─1042, 2006
3) Umayahara K, et al : Phase I study of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel chemotherapy for locally advanced cervical carcinoma in Japanese women. Int J Gynecol Cancer 19 : 723─727, 2009
4) Nagai Y, et al : Concurrent chemoradiotherapy with paclitaxel and cisplatin for adenocarcinoma of the cervix. Anticancer Res 32 : 1475─1479, 2012
5) Dueñas-González A, et al : Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J Clin Oncol 29 : 1678─1685, 2011
6) DiSilvestro PA, et al : Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis : a Gynecologic Oncology Group study. J Clin Oncol 32 : 458─464, 2014
7) Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer : a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol 26 : 5802─5812, 2008
8) Shueng PW, et al : Neoadjuvant chemotherapy followed by radiotherapy should not be a standard approach for locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 40 : 889─896, 1998
9) McCormack M, et al : A phase II study of weekly neoadjuvant chemotherapy followed by radical chemoradiation for locally advanced cervical cancer. Br J Cancer 108 : 2464─2469, 2013
10) Schefter TE, et al : A phase II study of bevacizumab in combination with definitive radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma : preliminary results of RTOG 0417. Int J Radiat Oncol Biol Phys 83 : 1179─1184, 2012
11) Schefter T, et al : RTOG 0417 : efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma. Int J Radiat Oncol Biol Phys 88 : 101─105, 2014
12) Moore KN, et al : A phase I trial of tailored radiation therapy with concomitant cetuximab and cisplatin in the treatment of patients with cervical cancer : a gynecologic oncology group study. Gynecol Oncol 127 : 456─461, 2012
13) Nogueira-Rodrigues A, et al : Phase 2 trial of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced cervical cancer. Cancer 120 : 1187─1193, 2014
14) Dimopoulos JC, et al : Dose-effect relationship for local control of cervical cancer by magnetic resonance image-guided brachytherapy. Radiother Oncol 93 : 311─315, 2009
15) Liang Y, et al : Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies. Int J Radiat Oncol Biol Phys 85 : 406─414, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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