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雑誌文献

臨床婦人科産科69巻3号

2015年04月発行

文献概要

今月の臨床 早産の予知・予防の新たな展開 早産の予知

2.子宮頸管生化学マーカーと早産予知

著者: 田中幹二1 湯澤映1 阿部和弘2 伊東麻美3

所属機関: 1弘前大学医学部附属病院周産母子センター 2独立行政法人国立病院機構弘前病院 3青森県立中央病院総合周産期母子医療センター

ページ範囲:P.288 - P.294

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●切迫早産の症状は特異的とはいえず原因も複合的であり,早産予知は容易ではない.

●早産減少と過剰治療減少の2つを両立させるのは困難だが,早産予知マーカーがその一助となる可能性がある.

●危険因子の有無を検討し,内診,頸管長測定,胎児性フィブロネクチン,時に顆粒球エラスターゼを併用して総合的に早産予知を行うのが現実的だろう.

参考文献

1) 田中幹二 : 切迫早産,ハイリスク妊娠の診療を極める.pp134─147,永井書店,2009
2) 松田義夫 : わが国の大規模case-control studyの成績からみた早産の予防戦略.産婦の実際55 : 17─22, 2006
3) Lockwood CJ, et al : Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N Eng J Med 325 : 669─674, 1991
4) Leeson SC, et al : Detection of fetal fibronectin as a predictor of preterm delivery in high risk symptomatic pregnancies. Br J Obstet Gynecol 103 : 48─53, 1996
5) 日本産婦人科学会,日本産婦人科医会 編 : CQ302 切迫早産の取り扱いは?,産婦人科診療ガイドライン産科編2014.pp134─138,日本産婦人科学会,2014
6) Committee on Practice Bulletins-Obstetrics, American College of Obstetricians and Gynecologists : Practice bulletin no. 130 : prediction and prevention of preterm birth. Obstet Gynecol 120 : 964─973, 2012
7) Cunningham FG, et al : Preterm Labor, Williams Obstetrics 24th ed. pp829─861, McGRAW-HILL, 2014
8) Leitich H, et al : Cervicovaginal fetal fibronectin as a marker for preterm delivery : a meta-analysis. Am J Obstet Gynecol 180 : 1169─1176, 1999
9) Honest H, et al : Screening to prevent spontaneous preterm birth : systematic reviews of accuracy and effectiveness literature with economic modeling. Health technol Assess 13 : 1─627, 2009
10) Peaceman AM, et al : Fetal fibronectin as a predictor of preterm birth in patients with symptoms : a multicenter trial. Am J Obstet Gynecol 177 : 13─18, 1997
11) Lowe MP, et al : Prospective randomized controlled trial of fetal fibronectin on preterm labor management in a tertiary care center. Am J Obste Gynecol 190 : 358─362, 2004
12) Iams JD, et al : The preterm prediction study : recurrence risk of spontaneous preterm birth. National Institute of Child health and human development maternal-fetal Medicine Network. Am J Obstet Gynecol 178 : 562─567, 1998
13) Gomez R, et al : Cervicovaginal fibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes. Am J Obstet Gynecol 192 : 350─359, 2005
14) Goldenberg RL, et al : The preterm prediction study : toward a multiple-marker test for spontaneous preterm birth. Am J Obstet Gynecol 185 : 643─651, 2001
15) 寺尾俊彦,他 : 妊婦頸管粘液中顆粒球エラスターゼ測定キットの開発とその臨床的意義.産婦の実際42 : 2021─2031, 1993
16) 平野秀人,他 : 絨毛膜羊膜炎の生化学的検査.周産期医30 : 171─176, 2000
17) Nakai A, et al : Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery. Gynecol Obstet Invest 60 : 87─91, 2005
18) Lembert A, et al : New rapid bedside test to predict preterm delivery. Acta Obstet Gynecol Scand 81 : 706─712, 2002
19) Lange M, et al : Elevation of interleukin-6 levels in cervical secretions as a predictor of preterm delivery. Acta Obstet Gynecol Scand 82 : 326─329, 2003
20) Hillier SL, et al : The relation ship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioaminon infection. Obstet Gynecol 81 : 941─948, 1993
21) Greig PC, et al : Maternal serum interleukin-6 during pregnancy and during term and preterm labor. Obstet Gynecol 90 : 465─469, 1997
22) Sakai M, et al : Evaluation of effectiveness of prophylactic cerclage of short cervix according to interleukin-8 in cervical mucus. Am J Obstet Gynecol 194 : 14─19, 2006
23) Yoneda S, et al : Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes. JOGR 33 : 38─44, 2007
24) Hee L : Likelihood ration for the prediction of preterm delivery with biomarkers. Acta Obstet Gynecol Scand 90 : 1189─1199, 2011
25) Menon R, et al : Biomarkers of spontaneous preterm birth : an overview of the literature in the last four decades. Reprod Sci 18 : 1046─1070, 2011
26) 田中幹二 : 切迫早産の成因・病態.産婦の実際59 : 861─868, 2010

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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