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雑誌文献

臨床婦人科産科69巻3号

2015年04月発行

文献概要

今月の臨床 早産の予知・予防の新たな展開 早産の予防

3.早産に対する黄体ホルモン療法の展望

著者: 藤田太輔1 寺井義人1 大道正英1

所属機関: 1大阪医科大学産婦人科学教室

ページ範囲:P.313 - P.319

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●早産既往妊婦あるいは子宮頸管短縮妊婦における黄体ホルモン投与は,早産を減少させ,児のアウトカムを改善させる.

●早産率の低い本邦において,黄体ホルモン投与がどの程度の早産予防効果があるのかを検証することは,これからの課題である.

参考文献

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2) Meis PJ, et al : Prevention of recurrent preterm delivery by 17 alpha- hydroxyprogesterone caproate. N Engl J Med 348 : 2379─2385, 2003
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9) da Fonseca EB, et al : Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk : a randomized placebo-controlled double-blind study. Am J Obstet Gynecol 188 : 419─424, 2003
10) Hassan SS, et al : PREGNANT Trial : Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix : a multicenter, randomized,double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 38 : 18─31, 2011
11) Su LL, et al : Progestational agents for treating threatened or established preterm labour. Cochrane Database Syst Rev 1 : CD006770, 2014
12) Sotiriadis A, et al : Perinatal outcome in women treated with progesterone for the prevention of preterm birth : a meta-analysis. Ultrasound Obstet Gynecol 40 : 257─266, 2012
13) Serra V, et al : Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies : a randomised controlled double-blind multicentre trial. BJOG 120 : 50─57, 2013
14) Durnwald CP : 17 OHPC for prevention of preterm birth in twins : back to the drawing board? Am J Obstet Gynecol 208 : 167─168, 2013
15) Romero R, et al : Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity : a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol 206 : 124. e1─19, 2012
16) Society for Maternal-Fetal Medicine Publications Committee, with assistance of Vincenzo Berghella : Progesterone and preterm birth prevention : translating clinical trials data into clinical practice. Am J Obstet Gynecol 20 : 376─386, 2012

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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